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Influenza A virus neuraminidase

2010; Springer Nature; Volume: 3; Issue: 2 Linguagem: Inglês

10.1038/scibx.2010.54

1945-3477

Rachel S. Kelly,

Virology and Viral Diseases

Influenza virusInfluenza A virus neuraminidaseAn in vitro study identified diarylheptanoid neuraminidase inhibitors that could be useful for treating influenza virus infection.In enzyme inhibition assays, plant-derived diarylheptanoid compounds inhibited neuraminidase from four H1N1 influenza A subtypes.Next steps include evaluating the efficacy and toxicity of the antivirals.Tamiflu oseltamivir, a neuraminidase inhibitor from Gilead Sciences Inc. and Roche, is marketed to treat and prevent influenza infection.Relenza zanamivir, an inhaled influenza neuraminidase inhibitor from Biota Holdings Ltd. and GlaxoSmithKline plc, is marketed to treat influenza infection.At least four other companies have neuraminidase inhibitors in Phase III testing to treat and prevent influenza infection.