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Characteristics and Outcome of AIDS-Related Hodgkin Lymphoma Before and After the Introduction of Highly Active Antiretroviral Therapy

2008; Lippincott Williams & Wilkins; Volume: 47; Issue: 4 Linguagem: Inglês

10.1097/qai.0b013e31815e722b

1944-7884

Juan Berenguer, Pilar Miralles, Josep‐María Ribera, Rafael Rubio, Eulalia Valencia, Beatriz Mahíllo, Vicente Pintado, Rosario Palacios, Marisa Montes, María Jesús Téllez, José La Cruz, José Miguel Cisneros, Francisco Rodríguez-Arrondo, María Antonia Sepúlveda, Félix Gutiérrez, Galo Peralta, Vicente Boix,

Hematopoietic Stem Cell Transplantation

Objectives: We analyzed survival, therapeutic response, and prognostic factors in patients with HIV-related Hodgkin lymphoma (HL) treated or not with highly active antiretroviral therapy (HAART). Methods: This study included 104 patients with HL, treated (n = 83) or not (n = 21) with HAART. Outcomes and prognostic factors of complete remission (CR), overall survival (OS), and disease-free survival (DFS) were assessed by an intention-to-treat analysis of all patients who received at least 1 chemotherapy course. Results: No differences were found between groups at baseline in the specific characteristics of HIV and HL. The proportion of patients receiving appropriate-for-stage therapy for HL was similar for both groups. The CR rates in the HAART (−) and HAART (+) groups were 14 (70%) of 20 versus 71 (91%) of 78 (P = 0.023). The median OS in the HAART (−) group was 39 months (95% confidence interval [CI]: 0 to 89) and was not reached in the HAART (+) group (P = 0.0089). The median DFS in the HAART (−) group was 85 months (95% CI: 73 to 97) and was not reached in the HAART (+) group (P = 0.129). Factors independently associated with CR by logistic regression analysis were appropriate-for-stage therapy of HL, HAART, and baseline CD4 count ≥100 cells/μL. CR was the only factor independently associated with OS by Cox regression analysis. Conclusions: The achievement of CR was independently associated with appropriate-for-stage therapy for HL, with HAART, and with a baseline CD4 count ≥100 cells/μL. The only variable independently associated with OS was the achievement of CR.