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The Relative Proportion of Stromal and Epithelial Hyperplasia is Related to the Development of Symptomatic Benign Prostate Hyperplasia

1992; Lippincott Williams & Wilkins; Volume: 147; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)37546-8

1527-3792

Ellen Shapiro, Michael J. Becich, Victor Hartanto, Herbert Lepor,

Urologic and reproductive health conditions

No AccessJournal of Urology1 May 1992The Relative Proportion of Stromal and Epithelial Hyperplasia is Related to the Development of Symptomatic Benign Prostate Hyperplasia Ellen Shapiro, Michael J. Becich, Victor Hartanto, and Herbert Lepor Ellen ShapiroEllen Shapiro , Michael J. BecichMichael J. Becich , Victor HartantoVictor Hartanto , and Herbert LeporHerbert Lepor View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37546-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The specific features of the prostate adenoma predisposing to the development of symptomatic benign prostatic hyperplasia (BPH) are unknown. Our objective was to determine whether the histological composition of the prostate adenoma is related to the development of symptomatic BPH. Prostate adenomas were obtained from men with asymptomatic BPH undergoing cystoprostatectomy for invasive transitional cell carcinoma, and from men with symptomatic BPH undergoing open prostatectomy, transurethral resection of the prostate and pharmacotherapy. The severity of bladder outlet obstruction was evaluated with the Boyarsky symptom score and uroflowmetry. The percentages of stroma, epithelium and glandular lumen were determined in the prostate adenomas via quantitative image analysis on a computer-assisted morphometry system. The prostate adenomas from the 33 men with symptomatic BPH contained 62 ± 1%, 15 ± 1% and 23 ± 1% of stroma, epithelium and glandular lumen, respectively. The prostate adenomas from 6 men with asymptomatic disease contained 54 ± 1%, 21 ± 1% and 25 ± 1% of stroma, epithelium and glandular lumen, respectively. The ratios of stromal-to-epithelial hyperplasia in the prostate adenomas from men with symptomatic and asymptomatic disease were 4.6 ± 0.3 and 2.7 ± 0.1, respectively. The differences in percentage of stroma and epithelium, and the stromal-to-epithelial ratio in the prostate adenomas from men with symptomatic and asymptomatic BPH were statistically significant. Our study suggests that the histological composition of the prostate adenoma is related to the development of symptomatic BPH. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByGupta N and McVary K (2016) Physiological and Pharmacological Studies of the Prostate GlandJournal of Urology, VOL. 197, NO. 2S, (S26-S27), Online publication date: 1-Feb-2017.Hinata N, Miyake H, Murakami G, Abe S and Fujisawa M (2018) Bladder Neck Muscle Degeneration in Patients with Prostatic HyperplasiaJournal of Urology, VOL. 195, NO. 1, (206-212), Online publication date: 1-Jan-2016.Matsukawa Y, Gotoh M, Komatsu T, Funahashi Y, Sassa N and Hattori R (2018) Efficacy of Silodosin for Relieving Benign Prostatic Obstruction: Prospective Pressure Flow StudyJournal of Urology, VOL. 189, NO. 1S, (S117-S121), Online publication date: 1-Jan-2013.Kojima Y, Sasaki S, Kubota Y, Imura M, Oda N, Kiniwa M, Hayashi Y and Kohri K (2018) Up-Regulation of α1a and 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Volume 147Issue 5May 1992Page: 1293-1297 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordsepitheliumprostatic diseasesprostatic hypertrophyMetricsAuthor Information Ellen Shapiro More articles by this author Michael J. Becich More articles by this author Victor Hartanto More articles by this author Herbert Lepor More articles by this author Expand All Advertisement Loading ...