Profile of pH, Pressure, and Potential Difference at Gastroduodenal Junction in Man
1965; Elsevier BV; Volume: 49; Issue: 4 Linguagem: Inglês
10.1016/s0016-5085(19)34511-1
ISSN1528-0012
AutoresSven Andersson, Morton I. Grossman,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoA method for exact localization of the gastroduodenal junction has not previously been available for use with intraluminal sensors.Unlike the gastroesophageal junction/ the gastroduodenal junction shows no identifying pressure profile. 2 In the present study we show that the change in transmural electrical potential difference (PD), measured from skin or blood to lumen, is a reliable means of identifying the gastroduodenal junction.• In situ measurements of pH of duodenal contents at levels near the pylorus have been unsatisfactory not only because of lack of a means of identifying the pylorus but also because of technical difficulties that caused rapid unexplained changes in apparent pH. 3 • 4 We have modified the method for measuring in situ pH with an intraluminal glass electrode and have obtained stable records of the pH of the gastroduodenal segment without unexplained rapid fluctuations. Methods Studies in Human SubjectsPressure measurements.The intraluminal pressure was recorded by a small rubber balloon
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