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The Dissolution of Cystine Stones by Irrigated Tiopronin Solution

1980; Lippincott Williams & Wilkins; Volume: 124; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)55657-8

1527-3792

Yoshimasa Hayase, Hidetoshi Fukatsu, Akio Segawa,

Urological Disorders and Treatments

No AccessJournal of Urology1 Dec 1980The Dissolution of Cystine Stones by Irrigated Tiopronin Solution Yoshimasa Hayase, Hidetoshi Fukatsu, and Akio Segawa Yoshimasa HayaseYoshimasa Hayase Current address: Department of Urology, Aichi Medical University, Nisshin-cho, Aichi-gun, Aichi-ken, Japan. More articles by this author , Hidetoshi FukatsuHidetoshi Fukatsu More articles by this author , and Akio SegawaAkio Segawa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)55657-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A new method involving the introduction of tiopronin solution directly into the renal pelvis or bladder has been developed for the treatment of cystine stones. Therapeutic irrigation by tiopronin solution was done in 4 cases of residual cystine kidney stones using a nephrostomy tube, and in an infant with bladder cystine stones using a Foley 3-way catheter. In every case all of the cystine stones were dissolved completely. During the course of the treatment no abnormality was noted on blood, liver function or immunological tests. Neither have there been any negative side effects, such as eruption, anorexia, nausea, diarrhea or general fatigue. The significance of this irrigation process is that whereas nephrectomy, heminephrectomy or nephrolithotomy was necessary previously to remove kidney cystine stones, now only pyelolithotomy and nephrostomy tube insertion are necessary. Furthermore, an operation is unnecessary in cases of bladder cystine stone dissolution by tiopronin irrigation. © 1980 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySinger A and Das S (2018) Cystinuria: A Review of the Pathophysiology and ManagementJournal of Urology, VOL. 142, NO. 3, (669-673), Online publication date: 1-Sep-1989.Dean Knoll L, Segura J, Patterson D, Leroy A and Smith L (2018) Long-Term Followup in Patients with Cystine Urinary Calculi Treated by Percutaneous Ultrasonic LithotripsyJournal of Urology, VOL. 140, NO. 2, (246-248), Online publication date: 1-Aug-1988.Saltzman N and Gittes R (2018) Chemolysis of Cystine CalculiJournal of Urology, VOL. 136, NO. 4, (846-849), Online publication date: 1-Oct-1986.Burns J and Hamrick L (2018) In Vitro Dissolution of Cystine Urinary CalculiJournal of Urology, VOL. 136, NO. 4, (850-852), Online publication date: 1-Oct-1986.Schmeller N, Kersting H, Schüller J, Chaussy C and Schmiedt E (2018) Combination of Chemolysis and Shock Wave Lithotripsy in the Treatment of Cystine Renal CalculiJournal of Urology, VOL. 131, NO. 3, (434-438), Online publication date: 1-Mar-1984.Griffith D (2018) Editorial CommentJournal of Urology, VOL. 131, NO. 3, (438-438), Online publication date: 1-Mar-1984.Tseng C, Talwalkar Y, Tank E, Hatch T and Alexander S (2018) Dissolution of Cystine Calculi by Pelviocaliceal Irrigation with Tromethamine-EJournal of Urology, VOL. 128, NO. 6, (1281-1283), Online publication date: 1-Dec-1982.Kuwahara M, Kambe K, Takahashi K, Orikasa S and Suzuki M (2018) Intermittent Irrigation System for Dissolution of Renal Calculi Monitored by ComputerJournal of Urology, VOL. 128, NO. 6, (1379-1381), Online publication date: 1-Dec-1982. Volume 124Issue 6December 1980Page: 775-778 Advertisement Copyright & Permissions© 1980 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Yoshimasa Hayase Current address: Department of Urology, Aichi Medical University, Nisshin-cho, Aichi-gun, Aichi-ken, Japan. More articles by this author Hidetoshi Fukatsu More articles by this author Akio Segawa More articles by this author Expand All Advertisement Loading ...