Cellular events during early formation of yolk-sac-derived teratomas
1982; The Company of Biologists; Volume: 70; Issue: 1 Linguagem: Inglês
10.1242/dev.70.1.225
ISSN1477-9129
AutoresH. Sobis, Luc Van den hove, Michel Vandeputte,
Tópico(s)Testicular diseases and treatments
ResumoA sequential morphological study of the initial cellular events in teratoma induction by displaced visceral yolk sac after foetectomy in rats was undertaken. This study led to the observation that apart from proliferation of cells displaying definite endodermal or mesodermal characteristics, a population of poorly differentiated cells appeared some days after the surgical procedure. It is very likely that these poorly differentiated cell are stem cells from which differentiated structures originate afterwards by a process of redifferentiation. The development of granulation tissue rich in capillaries seems to enhance this process. Similarities and differences with blastema formation are discussed.
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