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NHE 1 expression at wound margins increases time‐dependently during physiological healing

2016; Wiley; Volume: 26; Issue: 2 Linguagem: Inglês

10.1111/exd.13097

1600-0625

Sonja Haverkampf, Judith Heider, Katharina Weiß, Frank Haubner, Tobias Ettl, Julia Schreml, Sarah Hedtrich, Marietta von Süßkind‐Schwendi, Mark Berneburg, Sigrid Karrer, Joachim Dissemond, Stephan Schreml,

Burn Injury Management and Outcomes

Abstract Wound repair is an orchestrated process, encompassing the phases of inflammation, proliferation and tissue remodeling. In this context, sodium hydrogen exchanger 1 ( NHE 1) is crucial to epidermal barrier integrity and acidification. Recently, we found that extracellular pH ( pH e) on wound surfaces is dramatically increased initially after barrier disruption, and that pH e decreases gradually during physiological healing. Additionally, we have shown that spatial NHE 1‐patterns account for pH e‐gradients on surfaces of chronic wounds. Here, we show that NHE 1‐expression is very low at margins initially after wounding and that it increases massively during the time‐course of physiolgical healing. This finding is in accordance with the decrease of pH e on wound surfaces, which we reported on in previous works. Thus, we show that NHE 1 is an interesting target when it comes to modification of surface pH e on wounds, both acute and chronic, and that NHE 1 is time‐dependently regulated in physiological healing.