Altered Erythrocyte Cation Permeability in Familial Pseudohyperkalaemia
1989; Portland Press; Volume: 77; Issue: 2 Linguagem: Inglês
10.1042/cs0770213
ISSN1470-8736
AutoresGeorges Dagher, Marie‐Christine Vantyghem, Brief Créatif Agence Web Val d'Oise, G. Lallau, A Racadot, J Lefèbvre,
Tópico(s)Ion Transport and Channel Regulation
Resumo1. Erythrocyte cation transport pathways have been investigated in a family with pseudohyperkalaemia. 2. Ouabain- and bumetanide-resistant Na+ and K+ effluxes in three pseudohyperkalaemic patients were not different from those of control subjects when assessed at 37 degrees C. 3. When the temperature was decreased to 20 degrees C and 9 degrees C, K+ passive permeability markedly increased and Na+ permeability remained unchanged in these patients. In contrast, in control subjects a reduction in temperature caused a marked reduction in Na+ and K+ passive permeability. 4. These findings could account for the marked increase in plasma K+ concentration observed at subphysiological temperatures. 5. The Na+-K+ co-transport pathway was reduced in all members of the family, but the Na+-K+ pump was reduced in only two of them. These alterations were independent from the pseudohyperkalaemic state.
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