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High-Dose Adrenaline in Adult In-Hospital Asystolic Cardiopulmonary Resuscitation: A Double-Blind Randomised Trial

1993; SAGE Publishing; Volume: 21; Issue: 2 Linguagem: Inglês

10.1177/0310057x9302100210

1448-0271

Jeffrey Lipman, W.E. Wilson, S. Kobilski, Juan Scribante, Chair Henry C. Lee, Peter A. Kraus, D. James Cooper, J. Barr, D G Moyes,

Family and Patient Care in Intensive Care Units

Forty intensive care unit patients requiring cardiopulmonary resuscitation were randomised to receive either the standard dose of adrenaline (1 mg every five minutes) or high-dose adrenaline (10 mg every five minutes). In the majority of patients, overwhelming sepsis was the major contributing factor leading to cardiac arrest. In this group of patients no difference could be detected in response to high-dose adrenaline compared with the standard dose. Although no side-effects were noted with this high dose of adrenaline, more investigation is required prior to its routine use in cardiopulmonary resuscitation.