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Granulocyte Elastase, β-Thromboglobulin, and C3D during Acetate or Bicarbonate Hemodialysis with Hemophan® Compared to a Cellulose Acetate Membrane

1992; SAGE Publishing; Volume: 15; Issue: 1 Linguagem: Inglês

10.1177/039139889201500103

1724-6040

Bernd Stegmayr, Kim H. Esbensen, Ángela M. Gutiérrez, L. Lundberg, Bent Nielsen, C-E. Stroemsaeter, B. Wehle,

Muscle and Compartmental Disorders

Twenty-two patients were dialysed in a cross-over design using Hemophan® or cellulose acetate membranes. The dialysate buffer was acetate (n = 12) or bicarbonate (n = 10). Blood was sampled at 0, 15, 60 and 180 min and mean values were adjusted for changes in total protein in each sample. At 15 min during dialysis a decrease in leukocytes and platelets occurred with both membranes, irrespective of the buffer (Wilcoxon, p < 0.006). During dialysis, increases were found in granulocyte elastase inhibitor complex (E-α 1 -PI), β-thromboglobulin and C3d. β 2 -microgrobulin was not significantly changed in blood after dialysis with Hemophan® or cellulose acetate membranes with bicarbonate buffer. Side effects were more pronounced at 180 min during dialysis with bicarbonate in patients using cellulose acetate than with Hemophan® (p = 0.021, n = 8). Hemophan® seemed to be more favourable than cellulose acetate membranes in regard to leukopenia and E- α 1 -PI. The dialysate buffer may also alter membrane biocompatibility.