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Augmentation of chemosensitivity during mild exercise in normal man.

1972; American Physiological Society; Volume: 33; Issue: 6 Linguagem: Inglês

10.1152/jappl.1972.33.6.813

8750-7587

John V. Weil, E. Byrne-Quinn, I. E. Sodal, Jeff Kline, R. E. McCullough, Giles F. Filley,

Chronic Obstructive Pulmonary Disease (COPD) Research

ArticleAugmentation of chemosensitivity during mild exercise in normal man.J V Weil, E Byrne-Quinn, I E Sodal, J S Kline, R E McCullough, and G F FilleyJ V Weil, E Byrne-Quinn, I E Sodal, J S Kline, R E McCullough, and G F FilleyPublished Online:01 Dec 1972https://doi.org/10.1152/jappl.1972.33.6.813MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByPrimum non nocere; It’s time to consider altitude training as the medical intervention it actually is!13 December 2022 | Frontiers in Psychology, Vol. 13Peripheral hypercapnic chemosensitivity in trained and untrained females and males during exerciseLeah M. Mann, Jason S. Chan, Sarah A. Angus, Connor J. Doherty, Benjamin P. Thompson, Glen E. Foster, Richard L. Hughson, and Paolo B. Dominelli5 December 2022 | Journal of Applied Physiology, Vol. 133, No. 6Contribution of the carotid body to thermally mediated hyperventilation in humans12 July 2022 | The Journal of Physiology, Vol. 600, No. 15The Role of Pharmacological Treatment in the Chemoreflex Modulation14 June 2022 | Frontiers in Physiology, Vol. 13The physiology and pathophysiology of exercise hyperpneaAltered chemosensitivity to CO 2 during exercise10 June 2021 | Physiological Reports, Vol. 9, No. 11Face Masks and the Cardiorespiratory Response to Physical Activity in Health and DiseaseAnnals of the American Thoracic Society, Vol. 18, No. 3Ventilatory Responsiveness during Exercise and Performance Impairment in Acute Hypoxia16 July 2020 | Medicine & Science in Sports & Exercise, Vol. 53, No. 2Peripheral chemoresponsiveness during exercise in male athletes with exercise‐induced arterial hypoxaemia12 September 2020 | Experimental Physiology, Vol. 105, No. 11The muscle reflex and chemoreflex interaction: ventilatory implications for the exercising humanHsuan-Yu Wan, Joshua C. Weavil, Taylor S. Thurston, Vincent P. Georgescu, Amber D. Bledsoe, Jacob E. Jessop, Michael J. Buys, Russell S. Richardson, and Markus Amann30 September 2020 | Journal of Applied Physiology, Vol. 129, No. 4The exercise pressor reflex and chemoreflex interaction: cardiovascular implications for the exercising human27 April 2020 | The Journal of Physiology, Vol. 598, No. 12Breathing During Sleep and its Investigation21 February 2020Global REACH 2018: The influence of acute and chronic hypoxia on cerebral haemodynamics and related functional outcomes during cold and heat stressThe Journal of Physiology, Vol. 598, No. 2Effect of food intake on respiratory chemosensitivity to CO2 in young adults8 July 2019 | Journal of Physiological Anthropology, Vol. 38, No. 1Control of exercise hyperpnoea: Contributions from thin‐fibre skeletal muscle afferents6 October 2019 | Experimental Physiology, Vol. 104, No. 11Exercise-induced arterial hypoxemia; some answers, more questionsApplied Physiology, Nutrition, and Metabolism, Vol. 44, No. 6Effect of food intake on the ventilatory response to increasing core temperature during exerciseApplied Physiology, Nutrition, and Metabolism, Vol. 44, No. 1Interaction of hypoxia and vascular occlusion on cardiorespiratory responses during exercise16 December 2018 | Translational Sports Medicine, Vol. 69The Role Of Parafacial Neurons In The Control Of Breathing During Exercise10 January 2018 | Scientific Reports, Vol. 8, No. 1Hyperadditive ventilatory response arising from interaction between the carotid chemoreflex and the muscle mechanoreflex in healthy humansTalita M. Silva, Liliane C. Aranda, Marcelle Paula-Ribeiro, Diogo M. Oliveira, Wladimir M. Medeiros, Lauro C. Vianna, Luiz E. Nery, and Bruno M. Silva25 July 2018 | Journal of Applied Physiology, Vol. 125, No. 1Development of an anaesthetized-rat model of exercise hyperpnoea: an integrative model of respiratory control using an equilibrium diagram30 April 2018 | Experimental Physiology, Vol. 103, No. 5Panting as a human heat loss thermoeffectorThe control of ventilation during exercise: a lesson in critical thinkingRichard. M. Bruce1 December 2017 | Advances in Physiology Education, Vol. 41, No. 4Thermoregulatory responses to exercise at a fixed rate of heat production are not altered by acute hypoxiaGeoff B. Coombs, Matthew N. Cramer, Nicholas Ravanelli, Pascal Imbeault, and Ollie Jay18 May 2017 | Journal of Applied Physiology, Vol. 122, No. 5Central neural control of the cardiovascular system: current perspectivesRoger A. L. Dampney21 July 2016 | Advances in Physiology Education, Vol. 40, No. 3Sex Differences in Normal Pulmonary Structure and Function at Rest and During Exercise16 December 2015Restoring heat stress-associated reduction in middle cerebral artery velocity does not reduce fatigue in the heat6 May 2015 | Scandinavian Journal of Medicine & Science in Sports, Vol. 25Peripheral chemoreceptor control of cardiovascular function at rest and during exercise in heart failure patientsHeather Edgell, M. Sean McMurtry, Mark J. Haykowsky, Ian Paterson, Justin A. Ezekowitz, Jason R. B. Dyck, and Michael K. Stickland1 April 2015 | Journal of Applied Physiology, Vol. 118, No. 7Day-to-day variability in cardiorespiratory responses to hypoxic cycle exerciseApplied Physiology, Nutrition, and Metabolism, Vol. 40, No. 2Activation of the carotid chemoreflex secondary to muscle metaboreflex stimulation in menH. Edgell, and M. K. Stickland1 May 2014 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 306, No. 9New perspectives concerning feedback influences on cardiorespiratory control during rhythmic exercise and on exercise performance10 August 2012 | The Journal of Physiology, Vol. 590, No. 17Ventilation and Respiratory Mechanics1 April 2012Resting and exercise ventilatory chemosensitivity across the menstrual cycleMeaghan J. MacNutt, Mary Jane De Souza, Simone E. Tomczak, Jenna L. Homer, and A. William Sheel1 March 2012 | Journal of Applied Physiology, Vol. 112, No. 5Effect of inspired CO2 on the ventilatory response to high intensity exerciseRespiratory Physiology & Neurobiology, Vol. 180, No. 2-3Control of Breathing During Exercise1 January 2012Carotid chemoreceptor modulation of blood flow during exercise in healthy humans14 December 2011 | The Journal of Physiology, Vol. 589, No. 24Metabolism, Temperature, and Ventilation1 October 2011Hypoxia augments muscle sympathetic neural response to leg cyclingKeisho Katayama, Koji Ishida, Erika Iwamoto, Motoyuki Iemitsu, Teruhiko Koike, and Mitsuru Saito1 August 2011 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 301, No. 2Effect of CO2 on the ventilatory sensitivity to rising body temperature during exerciseKeiji Hayashi, Yasushi Honda, Natsuki Miyakawa, Naoto Fujii, Masashi Ichinose, Shunsaku Koga, Narihiko Kondo, and Takeshi Nishiyasu1 May 2011 | Journal of Applied Physiology, Vol. 110, No. 5Effects of fasting on hypoxic ventilatory responses and the contribution of histamine H1 receptors in mice25 December 2010 | The Journal of Physiological Sciences, Vol. 61, No. 2Hyperoxic chemoreflex sensitivity is impaired in patients with neurocardiogenic syncopeInternational Journal of Cardiology, Vol. 142, No. 1Exertional dyspnea-related acidotic and sympathetic responses in patients with sequelae of pulmonary tuberculosis20 January 2010 | The Journal of Physiological Sciences, Vol. 60, No. 3Control of breathingAcidosis and raised norepinephrine levels are associated with exercise dyspnoea in idiopathic pulmonary fibrosisRespirology, Vol. 14, No. 7Altered ventilatory responses to exercise testing in young adult men with obstructive sleep apneaRespiratory Medicine, Vol. 103, No. 7Sympathetic restraint of muscle blood flow during hypoxic exerciseMichael K. Stickland, Curtis A. Smith, Benjamin J. Soriano, and Jerome A. Dempsey1 May 2009 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 296, No. 5Control of ventilation in humans following intermittent hypoxiaApplied Physiology, Nutrition, and Metabolism, Vol. 33, No. 3Caffeine Stimulates Ventilation in Athletes with Exercise-Induced HypoxemiaMedicine & Science in Sports & Exercise, Vol. 40, No. 6Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exerciseNaoto Fujii, Yasushi Honda, Keiji Hayashi, Hideaki Soya, Narihiko Kondo, and Takeshi Nishiyasu1 April 2008 | Journal of Applied Physiology, Vol. 104, No. 4Cerebrovascular responsiveness to steady-state changes in end-tidal CO2 during passive heat stressDavid A. Low, Jonathan E. Wingo, David M. Keller, Scott L. Davis, Rong Zhang, and Craig G. Crandall1 April 2008 | Journal of Applied Physiology, Vol. 104, No. 4Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans17 March 2008 | The Journal of Physiology, Vol. 586, No. 6Relationship between resting ventilatory chemosensitivity and maximal oxygen uptake in moderate hypobaric hypoxiaTakeshi Ogawa, Keiji Hayashi, Masashi Ichinose, and Takeshi Nishiyasu1 October 2007 | Journal of Applied Physiology, Vol. 103, No. 4Carotid Chemoreceptor Modulation of Regional Blood Flow Distribution During Exercise in Health and Chronic Heart FailureCirculation Research, Vol. 100, No. 9The effects of hyperthermia and hypoxia on ventilation during low-intensity steady-state exerciseAaron L. Chu, Ollie Jay, and Matthew D. White1 January 2007 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 292, No. 1Prior sustained hypoxia attenuates interaction between hypoxia and exercise as ventilatory stimuli in humans12 January 2007 | Experimental Physiology, Vol. 92, No. 1Relationship Between β-Blocker Treatment and the Severity of Central Sleep Apnea in Chronic Heart FailureChest, Vol. 131, No. 1Components and mechanisms of thermal hyperpneaMatthew D. White1 August 2006 | Journal of Applied Physiology, Vol. 101, No. 2Hypoxic ventilatory response is correlated with increased submaximal exercise ventilation after live high, train low18 December 2004 | European Journal of Applied Physiology, Vol. 94, No. 1-2Carbon dioxide sensitivity during hypoglycaemia-induced, elevated metabolism in the anaesthetized rat8 March 2005 | The Journal of Physiology, Vol. 563, No. 3Nocturnal Continuous Positive Airway Pressure Improves Ventilatory Efficiency During Exercise in Patients With Chronic Heart FailureChest, Vol. 127, No. 3Impact of heart failure on quality of sleep8 February 2005 | Postgraduate Medical Journal, Vol. 81, No. 952Role of central sympathoexcitation in enhanced hypercapnic chemosensitivity in patients with heart failureAmerican Heart Journal, Vol. 148, No. 6Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patients with chronic heart failureJournal of Cardiac Failure, Vol. 10, No. 3Chemoreflex Drive and the Dynamics of Ventilation and Gas Exchange during Exercise at HypoxiaAmerican Journal of Respiratory and Critical Care Medicine, Vol. 168, No. 9Enhanced Ventilatory Response to Exercise in Patients With Chronic Heart Failure and Central Sleep ApneaCirculation, Vol. 107, No. 15Cardiorespiratory Responses to Hypoxia and Hypercapnia at Rest in Vocalists.The Japanese Journal of Physiology, Vol. 53, No. 1Hyperpnea training attenuates peripheral chemosensitivity and improves cycling enduranceJournal of Experimental Biology, Vol. 205, No. 24Living high-training low increases hypoxic ventilatory response of well-trained endurance athletesNathan E. Townsend, Christopher J. Gore, Allan G. Hahn, Michael J. McKenna, Robert J. Aughey, Sally A. Clark, Tahnee Kinsman, John A. Hawley, and Chin-Moi Chow1 October 2002 | Journal of Applied Physiology, Vol. 93, No. 4Circadian pattern of ventilation during acute and chronic hypercapnia in conscious adult ratsErin L. Seifert, and Jacopo P. Mortola1 January 2002 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 282, No. 1Chemoreflexsensitivity in chronic heart failure patients3 December 2001 | European Journal of Heart Failure, Vol. 3, No. 6Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in ratsRespiration Physiology, Vol. 127, No. 2-3Gas Exchange Efficiency in Congestive Heart Failure IICirculation, Vol. 103, No. 7Chemoreflexsensitivity in Patients with Survived Sudden Cardiac Arrest and Prior Myocardial InfarctionPacing and Clinical Electrophysiology, Vol. 23, No. 4Respiratory Compensation Point during Incremental Exercise as Related to Hypoxic Ventilatory Chemosensitivity and Lactate Increase in Man.The Japanese Journal of Physiology, Vol. 50, No. 4Human hypoxic ventilatory response with blood dopamine content under intermittent hypoxic trainingCanadian Journal of Physiology and Pharmacology, Vol. 77, No. 12Ventilatory chemosensitive adaptations to intermittent hypoxic exposure with endurance training and detrainingKeisho Katayama, Yasutake Sato, Yoshifumi Morotome, Norihiro Shima, Koji Ishida, Shigeo Mori, and Miharu Miyamura1 June 1999 | Journal of Applied Physiology, Vol. 86, No. 6Peripheral chemoreceptor function after carbonic anhydrase inhibition during moderate-intensity exerciseBarry W. Scheuermann, John M. Kowalchuk, Donald H. Paterson, and David A. Cunningham1 May 1999 | Journal of Applied Physiology, Vol. 86, No. 5Ventilation's role in the decline in ??VO2maxand SaO2 in acute hypoxic exerciseMedicine &Science in Sports &Exercise, Vol. 30, No. 2Augmented Peripheral Chemosensitivity as a Potential Input to Baroreflex Impairment and Autonomic Imbalance in Chronic Heart FailureCirculation, Vol. 96, No. 8Central Neural Control of Respiration and Circulation During Exercise1 January 2011Reflexes Controlling Circulatory, Ventilatory and Airway Responses to Exercise1 January 2011Ventilatory sensitivity to carbon dioxide: the influence of exercise and athleticismMedicine &Science in Sports &Exercise, Vol. 28, No. 6Hypoxic ventilatory response during rest and exercise after a Himalayan expeditionEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 73, No. 3-4Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failureJournal of the American College of Cardiology, Vol. 27, No. 3Cardiorespiratory Response to Progressive Leg Exercise under Acute Normobaric Hypoxia3 October 2008 | Archives of Physiology and Biochemistry, Vol. 104, No. 3Contribution of Peripheral Chemoreceptor Drive in Exercise Hyperpnea in Humans.APPLIED HUMAN SCIENCE Journal of Physiological Anthropology, Vol. 15, No. 6Hypoxic response is inversely related to degree of exercise hyperventilationRespiration Physiology, Vol. 101, No. 1Effects of fenoterol on ventilatory responses to hypoxia and hypercapnia in normal subjects.Thorax, Vol. 50, No. 2The Excitation of Carotid Body Chemoreceptors of the Cat by Potassium and NoradrenalineChange in the peripheral CO2 chemoreflex from rest to exerciseEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 70, No. 4Ventilatory response to CO2 and hypoxia during cold exposure in awake ratsRespiration Physiology, Vol. 99, No. 1Reflexes Arising from the Arterial ChemoreceptorsVentilatory responses to exercise and carbon dioxide in elderly and younger humansEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 66, No. 4References and further readingEffect of dopamine on ventilatory response to incremental exercise in manRespiration Physiology, Vol. 89, No. 2Modelling the dynamic ventilatory response to hypoxia in humansAnnals of Biomedical Engineering, Vol. 20, No. 2Changes in ventilation at the start and end of moderate and heavy exercise of short and long durationEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 65, No. 3Role of catecholamines and β-receptors in ventilatory response during hypoxic exerciseRespiration Physiology, Vol. 85, No. 1Peripheral Chemosensitivity Assessed by the Modified Transient O2 Test in Female TwinsChest, Vol. 100, No. 1Longitudinal Analyses of Respiratory Chemosensitivity in Normal SubjectsAmerican Review of Respiratory Disease, Vol. 143, No. 6The physiology of nutritional assessment and therapy in protein-calorie malnutritionDisease-a-Month, Vol. 36, No. 7Studies on Exercise Hyperpnea in Relation with Hypoxic Ventilatory Chemosensitivity Measured at RestEffects of atropine and propranolol on the respiratory, circulatory, and ECG responses to high altitude in manEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 57, No. 2The contribution of peripheral chemoreceptors to ventilation during heavy exerciseRespiration Physiology, Vol. 68, No. 2Ineffective Breathing Pattern Related to MalnutritionNursing Clinics of North America, Vol. 22, No. 1References and further readingHormones and Neurochemicals in the Regulation of Breathing1 January 2011Integration of Respiratory Responses to Changes in Alveolar Partial Pressures of CO2 and O 2 and in Arterial pH1 January 2011Anesthesia and the Control of Ventilation1 January 2011Increased metabolism contributes to increased resting ventilation at high altitudeRespiration Physiology, Vol. 57, No. 3Hypercapnic ventilation during exercise: Effects of exercise methods and inhalation techniquesRespiration Physiology, Vol. 50, No. 1Chemical Regulation of RespirationChest, Vol. 82, No. 4Interaction of CO2 and positive and negative exercise stimuli on the ventilation in manPfl�gers Archiv European Journal of Physiology, Vol. 394, No. 1Effects of positive and negative exercise on ventilatory CO2 sensitivityEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 47, No. 1Phrenic nerve afterdischarge after electrical stimulation of the carotid sinus nerve in catsRespiration Physiology, Vol. 45, No. 2Propranolol and the respiratory, circulatory, and ECG responses to high altitudeEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 46, No. 2Lack of effects of beta sympathetic blockade on the metabolic and respiratory responses to carbohydrate feedingMetabolism, Vol. 30, No. 5ASPECTS OF THE REGULATION OF RESPIRATION IN MUSCULAR EXERCISEINTERACTION OF HYPERCAPNIC VENTILATORY STIMULUS AND NEURAL AFFERENTS FROM THE MUSCLES IN MODERATE EXERCISEThe ventilatory response to carbon dioxide in hyperoxic exerciseRespiration Physiology, Vol. 40, No. 1CHEMICAL BREATHING CONTROLS: SLOW, INTERMEDIATE AND FASTClinics in Chest Medicine, Vol. 1, No. 1The contribution of the reflex hypoxic drive to the hyperpnoea of exerciseRespiration Physiology, Vol. 35, No. 1Hypoventilation in Obstructive Lung DiseaseNew England Journal of Medicine, Vol. 298, No. 10Clinical Semi-StarvationNew England Journal of Medicine, Vol. 295, No. 7Assessment of Ventilatory Response to Hypoxia Methods and InterpretationChest, Vol. 70, No. 1Role of the carotid chemoreceptors in the hyperpnea of exercise in the catRespiration Physiology, Vol. 26, No. 2Ventilatory response to CO2 at rest and during positive and negative work in normoxia and hyperoxiaPfl�gers Archiv European Journal of Physiology, Vol. 364, No. 1Chemical control of breathing in identical twin athletes9 July 2009 | Annals of Human Biology, Vol. 3, No. 5Chemical control of ventilation during hypoxic exerciseRespiration Physiology, Vol. 22, No. 3Ventilatory acclimatization to 3400 meters altitude in the hereford calfRespiration Physiology, Vol. 21, No. 3The Lazy Respiratory Center–or How to Recognize a Tired HorseChest, Vol. 66, No. 1The control system regulating breathing in man17 March 2009 | Quarterly Reviews of Biophysics, Vol. 6, No. 4Responsiveness of breathing control centers to CO2 And neurogenic stimuliRespiration Physiology, Vol. 19, No. 1Adrenaline Increases Carotid Body CO2 Sensitivity: An in vivo StudyPeripheral Chemoreceptor Activity on Exercise-Induced Hyperpnea in Human More from this issue > Volume 33Issue 6December 1972Pages 813-9 https://doi.org/10.1152/jappl.1972.33.6.813PubMed4643864History Published online 1 December 1972 Published in print 1 December 1972 Metrics