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Prostate Specific Antigen Levels After Radical Prostatectomy in Patients with Organ Confined and Locally Extensive Prostate Cancer

1992; Lippincott Williams & Wilkins; Volume: 147; Issue: 3 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)37429-3

1527-3792

Avi Stein, Jean B. deKernion, Robert B. Smith, Frederick J. Dorey, Hetal Patel,

Urologic and reproductive health conditions

No AccessJournal of UrologyPredicting and Monitoring Results of Therapy1 Mar 1992Prostate Specific Antigen Levels After Radical Prostatectomy in Patients with Organ Confined and Locally Extensive Prostate Cancer Avi Stein, Jean B. deKernion, Robert B. Smith, Frederick Dorey, and Hetal Patel Avi SteinAvi Stein More articles by this author , Jean B. deKernionJean B. deKernion More articles by this author , Robert B. SmithRobert B. Smith More articles by this author , Frederick DoreyFrederick Dorey More articles by this author , and Hetal PatelHetal Patel More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37429-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A total of 230 patients with localized prostate cancer underwent radical retropubic prostatectomy at UCLA (pathological stage T1–3 N0, M0). Classification into groups included 115 patients with organ confined disease (group 1), 82 with invasion into or through the capsule (group 2) and 33 with seminal vesicle involvement (group 3). Median followup was 48 months. The 10-year, cause-specific survival was 96%, 90% and 63%, and 5-year, clinical, disease-free survival was 91%, 79% and 58% for the 3 groups, respectively. Recent prostate specific antigen (PSA) levels were measured in most patients, even those operated upon many years ago. Of the patients 41 had detectable (0.4ng./ml. or greater) PSA levels without any other clinical evidence of progression and 15 with clinical evidence of progression had PSA levels in the detectable range at the time of clinical progression. When isolated detectable PSA was also considered an indicator of progression the 5-year and 10-year, disease-free rates were 61% and 41%, respectively. These data show that radical prostatectomy performed in patients with even microscopic invasion into the capsule, positive margins and seminal vesicle involvement is associated with a higher clinical progression rate than organ confined disease. If isolated detectable PSA is also considered an indicator of recurrence the disease-free survival after radical prostatectomy might be less than indicated by previous studies. The relationship among survival, local tumor extension and PSA must be carefully examined. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByWARD J, SANDS J, NOWACKI M and AMLING C (2018) MALIGNANT CYTOLOGICAL WASHINGS FROM PROSTATE SPECIMENS: : AN INDEPENDENT PREDICTOR OF BIOCHEMICAL PROGRESSION AFTER RADICAL PROSTATECTOMYJournal of Urology, VOL. 165, NO. 2, (469-473), Online publication date: 1-Feb-2001.BLUTE M, BERGSTRALH E, PARTIN A, WALSH P, KATTAN M, SCARDINO P, MONTIE J, PEARSON J, SLEZAK J and ZINCKE H (2018) VALIDATION OF PARTIN TABLES FOR PREDICTING PATHOLOGICAL STAGE OF CLINICALLY LOCALIZED PROSTATE CANCERJournal of Urology, VOL. 164, NO. 5, (1591-1595), Online publication date: 1-Nov-2000.AMLING C, BLUTE M, BERGSTRALH E, SEAY T, SLEZAK J and ZINCKE H (2018) LONG-TERM HAZARD OF PROGRESSION AFTER RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER: CONTINUED RISK OF BIOCHEMICAL FAILURE AFTER 5 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the Progression of Poorly Differentiated Prostate Cancer?Journal of Urology, VOL. 152, NO. 5 Part 2, (1843-1849), Online publication date: 1-Nov-1994.Beck J, Kattan M and Miles B (2018) A Critique of the Decision Analysis for Clinically Localized Prostate CancerJournal of Urology, VOL. 152, NO. 5 Part 2, (1894-1899), Online publication date: 1-Nov-1994.Shinohara K, Wolf J, Narayan P and Carroll P (2018) Comparison of Prostate Specific Antigen with Prostate Specific Antigen Density for 3 Clinical ApplicationsJournal of Urology, VOL. 152, NO. 1, (120-123), Online publication date: 1-Jul-1994.Zietman A, Coen J, Shipley W, Willett C and Efird J (2018) Radical Radiation Therapy in the Management of Prostatic Adenocarcinoma: The Initial Prostate Specific Antigen Value as a Predictor of Treatment OutcomeJournal of Urology, VOL. 151, NO. 3, (640-645), Online publication date: 1-Mar-1994. 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Volume 147Issue 3 Part 2March 1992Page: 942-946 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordsprostatectomyantigensprostatic neoplasmsdifferentiationMetricsAuthor Information Avi Stein More articles by this author Jean B. deKernion More articles by this author Robert B. Smith More articles by this author Frederick Dorey More articles by this author Hetal Patel More articles by this author Expand All Advertisement Loading ...