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RENAL BIOPSY

1961; Royal Australasian College of Physicians; Volume: 10; Issue: 3 Linguagem: Inglês

10.1111/imj.1961.10.3.178

0571-9283

Ian R. Mackay, L. I. Taft,

Chronic Kidney Disease and Diabetes

Summary In this study diagnostically adequate tissue was obtained by aspiration biopsy of the kidney in 200 (78%) of the 257 patients investigated. Diabetic nephropathy most often complicated long‐standing diabetes ; but diabetic renal lesions did not depend on the duration and severity of the diabetes or on the degree of diabetic control with insulin. Twenty‐five patients with lupus nephritis were treated with cortisone ; “ mild ” and “ moderate ” glomerular lesions showed histological arrest ; but improvement was exceptional. Histological study of 38 cases of subacute glomerulo‐nephritis supported the validity of Allen's (1955) classification. In a limited analysis, the long‐term prognosis of patients treated with cortisone was not significantly better than that of untreated cases. A fluorescent antibody reagent was applied to a portion of the renal biopsy specimen in 71 cases, in order to determine the possible part played by antibodies in the production of nephritis. Positive reactions, suggesting localization of human globulin in the glomerulus, were obtained chiefly in lupus nephritis and in diffuse membranous glomerulo‐nephritis. Renal biopsy proved of most value in early diffuse renal disease wherein diagnosis, prognosis and probable response to treatment are best assessed on morphological grounds ; it was of less value in advanced renal disease with sclerosis.