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Bladder Permeability in Interstitial Cystitis is Similar to That of Normal Volunteers: Direct Measurement by Transvesical Absorption of 99m technetium-Diethylenetriaminepentaacetic Acid

1994; Lippincott Williams & Wilkins; Volume: 151; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(17)34945-5

1527-3792

Mark J. Chelsky, Scott I. Rosen, Linda Knight, Alan H. Maurer, Philip M. Hanno, Michael R. Ruggieri,

Urological Disorders and Treatments

No AccessJournal of UrologyReview Article1 Feb 1994Bladder Permeability in Interstitial Cystitis is Similar to That of Normal Volunteers: Direct Measurement by Transvesical Absorption of 99mtechnetium-Diethylenetriaminepentaacetic Acid Mark J. Chelsky, Scott I. Rosen, Linda C. Knight, Alan H. Maurer, Philip M. Hanno, and Michael R. Ruggieri Mark J. ChelskyMark J. Chelsky , Scott I. RosenScott I. Rosen , Linda C. KnightLinda C. Knight , Alan H. MaurerAlan H. Maurer , Philip M. HannoPhilip M. Hanno , and Michael R. RuggieriMichael R. Ruggieri View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)34945-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Bladder permeability was directly measured with the radionuclide used clinically for detecting vesicoureteral reflux (99mtechnetium-diethylenetriaminepentaacetic acid, 99mTc-DTPA) in 10 interstitial cystitis patients diagnosed according to National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases criterion and compared to 9 sex matched, symptom-free, normal volunteers. After functional bladder capacity was determined (capacity at which the patient demands fluid inflow to stop), the bladder was emptied and 5mCi. 99mTc-DTPA in 10ml. of saline were infused followed by normal saline to 80% of functional capacity. This was done to normalize the patients to the same low bladder pressure, since previous studies of rabbits indicated that bladder permeability is low and not significantly different at 20% and 60% of anesthetized bladder capacity (defined as the volume producing an intravesical pressure of 20cm. water). Radioactivity of 1ml. serum specimens taken at 0, 2, 15 and 30minutes after radionuclide infusion was determined in a gamma counter, corrected for radioactive decay and converted to per cent of instilled dose per whole body based on blood volume estimated from body weight for each individual. There was considerable interindividual variability in the absorption between the patients and the volunteers. Analysis of variance of these data showed no statistically significant difference between the patients and controls at any time sampled. These results indicate that while some interstitial cystitis patients have a more permeable bladder than others, the same is true for normal, symptom-free volunteers. Thus, the concept of increased bladder permeability in interstitial cystitis is not supported by this direct measurement of bladder permeability. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByTowner R, Wisniewski A, Wu D, Van Gordon S, Smith N, North J, McElhaney R, Aston C, Shobeiri S, Kropp B, Greenwood-Van Meerveld B and Hurst R (2018) A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial CystitisJournal of Urology, VOL. 195, NO. 3, (631-638), Online publication date: 1-Mar-2016.PARSONS C, GREENE R, CHUNG M, STANFORD E and SINGH G (2018) ABNORMAL URINARY POTASSIUM METABOLISM IN PATIENTS WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 173, NO. 4, (1182-1185), Online publication date: 1-Apr-2005.DAHA L, RIEDL C, HOHLBRUGGER G, KNOLL M, ENGELHARDT P and PFLÜGER H (2018) Comparative Assessment of Maximal Bladder Capacity, 0.9% NaCl Versus 0.2 M Kcl, for the Diagnosis of Interstitial Cystitis: A Prospective Controlled StudyJournal of Urology, VOL. 170, NO. 3, (807-809), Online publication date: 1-Sep-2003.WESTROPP J and BUFFINGTON C (2018) IN VIVO MODELS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 2 Part 1, (694-702), Online publication date: 1-Feb-2002.Parsons C and Albo M (2018) Intravesical Potassium Sensitivity in Patients With ProstatitisJournal of Urology, VOL. 168, NO. 3, (1054-1057), Online publication date: 1-Sep-2002.BOUCHER W, LETOURNEAU R, HUANG M, KEMPURAJ D, GREEN M, SANT G and THEOHARIDES T (2018) INTRAVESICAL SODIUM HYALURONATE INHIBITS THE RAT URINARY MAST CELL MEDIATOR INCREASE TRIGGERED BY ACUTE IMMOBILIZATION STRESSJournal of Urology, VOL. 167, NO. 1, (380-384), Online publication date: 1-Jan-2002.ERICKSON D, HERB N, ORDILLE S, HARMON N and BHAVANANDAN V (2018) A NEW DIRECT TEST OF BLADDER PERMEABILITYJournal of Urology, VOL. 164, NO. 2, (419-422), Online publication date: 1-Aug-2000.CHIANG G, PATRA P, LETOURNEAU R, JEUDY S, BOUCHER W, GREEN M, SANT G and THEOHARIDES T (2018) PENTOSANPOLYSULFATE INHIBITS MAST CELL HISTAMINE SECRETION AND INTRACELLULAR CALCIUM ION LEVELS:: AN ALTERNATIVE EXPLANATION OF ITS BENEFICIAL EFFECT IN INTERSTITIAL CYSTITISJournal of Urology, VOL. 164, NO. 6, (2119-2125), Online publication date: 1-Dec-2000.WEI D, POLITANO V, SELZER M and LOKESHWAR V (2018) THE ASSOCIATION OF ELEVATED URINARY TOTAL TO SULFATED GLYCOSAMINOGLYCAN RATIO AND HIGH MOLECULAR MASS HYALURONIC ACID WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 163, NO. 5, (1577-1583), Online publication date: 1-May-2000. 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Volume 151Issue 2February 1994Page: 346-349 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordsbladdercystitisradionuclide imagingMetricsAuthor Information Mark J. Chelsky More articles by this author Scott I. Rosen More articles by this author Linda C. Knight More articles by this author Alan H. Maurer More articles by this author Philip M. Hanno More articles by this author Michael R. Ruggieri More articles by this author Expand All Advertisement PDF DownloadLoading ...