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Absorption of Intraperitoneally Injected Amipaque in the Rabbit

1982; SAGE Publishing; Volume: 23; Issue: 3A Linguagem: Inglês

10.1177/028418518202303a10

0567-8056

Mervyn D. Cohen, R. J. Rust,

Advanced Drug Delivery Systems

The appearances of intraperitoneally injected Amipaque and the absorption rate are described. At 30 min after injection the peritoneal concentration was decreased and the urinary tract began to fill. At one hour, almost all Amipaque had disappeared from the peritoneal cavity and the urinary tract was well demonstrated. As absorption of Amipaque from the gastrointestinal tract is minimal, bowel perforation is thus indicated if, after oral administration, it appears in either the peritoneal cavity or the urinary tract.