Portal de Periódicos da CAPES

Spiranoid Withanolides from Jaborosa o donelliana

2002; American Chemical Society; Volume: 65; Issue: 7 Linguagem: Inglês

10.1021/np0200109

1520-6025

Adriana M. Cirigliano, Adriana S. Veleiro, Juan C. Oberti, Gerardo Burton,

Pharmacological Effects of Medicinal Plants

Six new spiranoid withanolides, (20R,22R,23S)-5α-chloro-6β,12β,17β,22-tetrahydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (2), (20R,22R,23S)-5β,6β-epoxy-12β,17β,22-trihydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (3), (20R,22R,23S)-5β,6β-epoxy-4β,12β,17β,22-tetrahydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (4), (20R,22R,23S)-5α,6β,12β,17β,22-pentahydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (5), (20R,22R,23S)-6β,12β,17β,22-tetrahydroxy-5α-methoxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (6), and (20R,22R,23S)-6β,12β,17β,22-tetrahydroxy-2α,5α-epidioxy-1-oxo-12,23-cycloergosta-3,24-dien-26,23-olide (7), were isolated from the leaves of Jaborosa odonelliana. Compounds 2−7 were characterized by a combination of spectroscopic methods (1D and 2D NMR, MS) and molecular modeling.