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Squamous Cell Carcinoma of the Bladder Associated with Cyclophosphamide Therapy for Wegener’s Granulomatosis: A Report of 2 Cases

1993; Lippincott Williams & Wilkins; Volume: 149; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(17)36156-6

1527-3792

John P. Stein, Eila C. Skinner, Stuart D. Boyd, Donald G. Skinner,

Nephrotoxicity and Medicinal Plants

No AccessJournal of Urology1 Mar 1993Squamous Cell Carcinoma of the Bladder Associated with Cyclophosphamide Therapy for Wegener's Granulomatosis: A Report of 2 Cases John P. Stein, Eila C. Skinner, Stuart D. Boyd, and Donald G. Skinner John P. SteinJohn P. Stein , Eila C. SkinnerEila C. Skinner , Stuart D. BoydStuart D. Boyd , and Donald G. SkinnerDonald G. Skinner View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36156-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Cyclophosphamide has been used to treat a variety of malignant and nonmalignant diseases. The association of this agent with the development of urothelial tumors has been well documented. Although most bladder cancers associated with prior cyclophosphamide therapy are transitional cell carcinoma, to our knowledge there have been 6 reports of cyclophosphamide-induced squamous cell carcinoma of the bladder. We report 2 additional cases of squamous cell carcinoma of the bladder that occurred in patients after cyclophosphamide treatment for Wegener's granulomatosis. Any patient with a history of prolonged cyclophosphamide ingestion needs careful long-term monitoring of the lower urinary tract, since there is at least a 9-fold increase in the incidence of lower urinary tract malignancy in such patients. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByDE RIDDER D, van POPPEL H, DEMONTY L, D'HOOGHE B, GONSETTE R, CARTON H and BAERT L (2018) BLADDER CANCER IN PATIENTS WITH MULTIPLE SCLEROSIS TREATED WITH CYCLOPHOSPHAMIDEJournal of Urology, VOL. 159, NO. 6, (1881-1884), Online publication date: 1-Jun-1998. Volume 149Issue 3March 1993Page: 588-589 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.KeywordsWegener's granulomatosiscarcinoma, squamous cellcyclophosphamidebladder neoplasmsMetricsAuthor Information John P. Stein More articles by this author Eila C. Skinner More articles by this author Stuart D. Boyd More articles by this author Donald G. Skinner More articles by this author Expand All Advertisement PDF DownloadLoading ...