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Effect of Chronic Ischemia on Glucose Metabolism of Rabbit Urinary Bladder

1989; Lippincott Williams & Wilkins; Volume: 142; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(17)39011-0

1527-3792

Alex Tong‐Long Lin, Frederick C. Monson, Kumiko Kato, Niels Haugaard, Alan J. Wein, Robert M. Levin,

Thermoregulation and physiological responses

No AccessJournal of Urology1 Oct 1989Effect of Chronic Ischemia on Glucose Metabolism of Rabbit Urinary Bladder Alex Tong-Long Lin, Frederick C. Monson, Kumiko Kato, Niels Haugaard, Alan J. Wein, and Robert M. Levin Alex Tong-Long LinAlex Tong-Long Lin More articles by this author , Frederick C. MonsonFrederick C. Monson More articles by this author , Kumiko KatoKumiko Kato More articles by this author , Niels HaugaardNiels Haugaard More articles by this author , Alan J. WeinAlan J. Wein More articles by this author , and Robert M. LevinRobert M. Levin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39011-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The effect of chronic ischemia on glucose metabolism of the rabbit urinary bladder was studied. Unilateral ischemia was produced by ligation of one of the two vesical arteries which supply the rabbit bladder. Two weeks after the operation, the in vitro glucose metabolism of normal bladder tissue was compared to the glucose metabolism of tissue isolated from both the ischemic side and contralateral (non-ischemic) side of the ischemic bladder. The results can be summarized as follows: 1) ischemic and contralateral side bladder tissues contained less glycogen than normal; 2) glucose utilization was higher in the ischemic and contralateral side tissues; 3) ischemic and contralateral side tissues incorporated more glucose into lactate and produced more total lactate than normal tissues; 4) whereas contralateral side tissue produced more 14CO2 than ischemic side tissue, the ability of normal bladder tissue to form 14CO2 is significantly higher than both ischemic and contralateral side tissues; 5) the degree of reduced CO2 production correlated well with previous studies on the contractile response of smooth muscle strips isolated from the ischemic and contralateral sides, and the reduced functional ability of the in vitro whole bladder to empty; 6) histologically, smooth muscle degeneration and necrosis is only present on the ischemic side of the bladder although the contralateral side shows signs of generalized degeneration and edema. In general, we conclude that although only the ischemic tissue demonstrated major smooth muscle degeneration and necrosis, unilateral ischemia resulted in marked alterations in glucose metabolism on both the ischemic and contralateral sides. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAZADZOI K, TARCAN T, KOZLOWSKI R, KRANE R and SIROKY M (2018) OVERACTIVITY AND STRUCTURAL CHANGES IN THE CHRONICALLY ISCHEMIC BLADDERJournal of Urology, VOL. 162, NO. 5, (1768-1778), Online publication date: 1-Nov-1999. Volume 142Issue 4October 1989Page: 1127-1133 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Alex Tong-Long Lin More articles by this author Frederick C. Monson More articles by this author Kumiko Kato More articles by this author Niels Haugaard More articles by this author Alan J. Wein More articles by this author Robert M. Levin More articles by this author Expand All Advertisement PDF downloadLoading ...