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Urothelial Injury from Ethylenediaminetetraacetic Acid Used as an Irrigant in the Urinary Tract

1989; Lippincott Williams & Wilkins; Volume: 142; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)39098-5

1527-3792

Michael H. Kane, John S. Rodman, Bruce Horten, Jon M. Reckler, D. Marion, E. Darracott Vaughan,

Traumatic Ocular and Foreign Body Injuries

No AccessJournal of Urology1 Nov 1989Urothelial Injury from Ethylenediaminetetraacetic Acid Used as an Irrigant in the Urinary Tract Michael H. Kane, John S. Rodman, Bruce Horten, Jon Reckler, Donald Marion, and E. Darracott Vaughan Michael H. KaneMichael H. Kane More articles by this author , John S. RodmanJohn S. Rodman More articles by this author , Bruce HortenBruce Horten More articles by this author , Jon RecklerJon Reckler More articles by this author , Donald MarionDonald Marion More articles by this author , and E. Darracott VaughanE. Darracott Vaughan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39098-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Although solutions containing disodium ethylenediaminetetraacetic acid (EDTA) will dissolve calcium oxalate stones in vitro, the safety of such solutions as urinary tract irrigants is questionable. These studies were designed to assess the degree of urothelial damage produced by the mildest EDTA formulation which has been reported to be effective. Rabbit bladders were irrigated antegrade via a ureterotomy for 20hours and then removed for histological examination. A 0.03M solution of disodium EDTA at pH 7.5 produced considerably more urothelial injury than did an otherwise identical solution of calcium EDTA (p = 0.006). The bladders from the latter group were undistinguishable from those irrigated with saline. As prior saturation of EDTA with calcium completely eliminated the tissue injury, these studies indicate that the same calcium chelating property which makes this chemical effective also makes it toxic. There was enough tissue damage from the relatively mild formulation used to suggest no EDTA solution yet formulated is safe for clinical use. (J. Urol., 142: 1359–1360, 1989) © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byOosterlinck W, Verbeeck R, Cuvelier C, Vergauwe D and Rappe B (2018) Toxicity to the Urothelium of Calcium Chelating Agents for ChemolysisJournal of Urology, VOL. 146, NO. 5, (1395-1397), Online publication date: 1-Nov-1991. Volume 142Issue 5November 1989Page: 1359-1360 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Michael H. Kane More articles by this author John S. Rodman More articles by this author Bruce Horten More articles by this author Jon Reckler More articles by this author Donald Marion More articles by this author E. Darracott Vaughan More articles by this author Expand All Advertisement PDF downloadLoading ...