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Pulmonary Toxicity of Inhaled Aerosolized Prostacyclin Therapy—An Observational Study

2000; SAGE Publishing; Volume: 28; Issue: 2 Linguagem: Inglês

10.1177/0310057x0002800206

1448-0271

Peter Vernon van Heerden, Paul Caterina, Pierre Filion, Dominic V. Spagnolo, N. M. Gibbs,

Respiratory and Cough-Related Research

Large white/landrace piglets (mass 11 to 21 kg) were exposed to aerosolized alkaline glycine diluent (n = 2) or inhaled aerosolized prostacyclin (n = 2) for five to eight hours. Pigs receiving these aerosols developed mild acute sterile tracheitis, involving the superficial layers of the trachea, shown histologically and ultrastructurally. Pigs receiving the diluent aerosol also showed mild inflammatory changes in the bronchioles. These findings suggest caution with the use of high volumes of aerosolized alkaline glycine diluent during inhaled aerosolized prostacyclin therapy.