Regulation of metallothionein gene transcription by metals.
1990; National Institutes of Health; Volume: 8; Linguagem: Inglês
Autores
Jean Imbert, Valeria Culotta, Peter Fürst, Lashitew Gedamu, Dean H. Hamer,
Tópico(s)Trace Elements in Health
ResumoThis review describes current progress in answering these questions. The first section focuses on work on metallothionein gene transcription in a very simple eukaryote, the unicellular yeast Saccharomyces cerevisiae. The ease of genetic manipulation of this organism has allowed cloning of the gene for the regulatory factor, to determine the basic mechanism of its activation and to begin studying MT gene regulation at the level of bioinorganic chemistry. The second section deals with MT gene regulation in mammals and fish. The cis-acting control sequences in these more complex higher organisms are now well defined and a good start has been made on the detection and purification of the regulatory factors. The final section takes a comparative look at MT gene regulation
Referência(s)