Adenylate cyclase activity as a function of forskolin concentration.
1985; National Institutes of Health; Volume: 10; Issue: 1 Linguagem: Inglês
Autores Tópico(s)
Monoclonal and Polyclonal Antibodies Research
ResumoThe activation of adenylate cyclase by forskolin was investigated in terms of the dissociation model of guanyl nucleotide binding protein (Ns). It was demonstrated that the biphasic forskolin concentration-response of adenylate cyclase could be explained by the dissociation of the beta subunit. The equations developed from such a theoretical approach gave an accurate description of concentration response data from S49 cultured mouse lymphoma cells.
Referência(s)