IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection
2015; Lippincott Williams & Wilkins; Volume: 29; Issue: 14 Linguagem: Inglês
10.1097/qad.0000000000000773
ISSN1473-5571
AutoresLuís Miguel Real, Rocío Herrero, António Rivero‐Juarez, Ángela Camacho, Juan Macı́as, Sandra Vic, Vincent Soriano, Sergio Viedma, Josep M. Guardiola, Joan Fibla, Antonio Rivero, Juan A. Pineda, Antonio Carúz,
Tópico(s)HIV Research and Treatment
ResumoThe interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments. The role of this polymorphism in HIV-1 infection is controversial. We investigated whether genetic variation at IFNL4 is associated to HIV-1 acquisition. The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous drug users [odds ratio (OR): 0.3; P = 0.006], and this association was not modified by the genotype of CCR5. These results suggest that genetic susceptibility to HCV and HIV-1 infection shares common molecular pathways.
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