Portal de Periódicos da CAPES

Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions

2016; American Society for Clinical Investigation; Volume: 126; Issue: 7 Linguagem: Inglês

10.1172/jci86198

1558-8238

Martina Absinta, Pascal Sati, Matthew K. Schindler, Emily Leibovitch, Joan Ohayon, Tianxia Wu, Alessandro Meani, Massimo Filippi, Steven Jacobson, Irene Cortese, Daniel S. Reich,

Skin and Cellular Biology Research

BACKGROUND. In some active multiple sclerosis (MS) lesions, a strong immune reaction at the lesion edge may contain growth and thereby isolate the lesion from the surrounding parenchyma. Our previous studies suggest that this process involves opening of the blood-brain barrier in capillaries at the lesion edge, seen on MRI as centripetal contrast enhancement and a colocalized phase rim. We hypothesized that using these features to characterize early lesion evolution will allow in vivo tracking of tissue degeneration and/or repair, thus improving the evaluation of potential therapies for chronic active lesions.