Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats.
1988; Elsevier BV; Volume: 29; Issue: 4 Linguagem: Inglês
10.1016/s0022-2275(20)38517-5
ISSN1539-7262
AutoresJacob Bar‐Tana, G Rose-Kahn, Boris Frenkel, Z. Shafer, M Fainaru,
Tópico(s)Liver Disease Diagnosis and Treatment
Resumo260: [8404][8405][8406][8407][8408][8409][8410] resulted in an acute reversible inhibition of liver lipogenesis and cholesterogenesis with a concomitant hypolipidemic effect which was sustained as long as the drug was administered.The hypolipidemic effect in normal and nephrotic rats consisted of 70-80% and 40-60% reduction in plasma VLDLtriacylglycerols and cholesterol, respectively, with a respective increase in the HDL-cholesterol/(VLDL + LDL)-cholesterol ratio.The observed hypolipidemic effect was accompanied by a 10-fold decrease in VLDL-apoC-I11 content with a concomitant enrichment of the VLDL fraction by VLDL remnants having an increased apoB-100/apoB-48 ratio.The pharmacological reduction of VLDL by MEDICA 16 may offer a treatment mode of choice for selected hyperlipidemic states.-
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