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Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014

2015; Centers for Disease Control and Prevention; Volume: 22; Issue: 1 Linguagem: Inglês

10.3201/eid2201.151340

1080-6059

Basem Alraddadi, John T. Watson, Abdulatif Almarashi, Glen R. Abedi, Amal Turkistani, Musallam Sadran, Abeer Housa, Mohammad A. AlMazroa, Naif Alraihan, Ayman Banjar, Eman Albalawi, Hanan Alhindi, Abdul Jamil Choudhry, Jonathan Meiman, Magdalena M. Paczkowski, Aaron T. Curns, Anthony W. Mounts, Daniel R. Feikin, Nina Marano, David L. Swerdlow, Susan I. Gerber, Rana Hajjeh, Tariq A. Madani,

COVID-19 Clinical Research Studies

Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of MERS-CoV.