Portal de Periódicos da CAPES

A comparison of fentanyl, droperidol, and morphine

1965; Wiley; Volume: 6; Issue: 6 Linguagem: Inglês

10.1002/cpt196566731

1532-6535

C. W. Gorodeizky, W R Martin,

Chemical synthesis and alkaloids

Single intramuscular doses of fentanyl, droperidol, fentanyl plus droperidol, morphine, and placebo were compared in a double‐blind, cross‐over study on 6 normal male postnarcotic addicts. Miotic effects were assessed by pupillography, opiate signs and symptoms, and liking by questionnaires. Fentanyl alone was foltnd to be similar to morphine in its pattern of signs and symptoms and its high frequency of identification as a narcotic. For equimiotic doses, fentanyl is at least as euphorogenic as morphine. In the combination of fentanyl plus droperidol, droperidol alters some of the morphinelike effects of the mixture, making the mixture similar to droperidol alone. However, if the dose of fentanyl in the mixture is increased, more of its morphinelike effects emerge. For equimiotic doses the combination is not more euphorogenic than morphine or fentanyl alone. The time courses of fentanyl, droperidol, and fentanyl plus droperidol are similar and differ from morphine in their shorter duration of action. All effects of the combination of fentanyl plus droperidol could be accounted for by the additive effects of each drug alone. Therefore, droperidol does not potentiate any of the effects of fentanyl. Extrapyramidal reactions were noted in 7 of 15 subjects who received single intramuscular doses of droperidol alone, and in one of 8 subjects who received single intramuscular doses of fentanyl plus droperidol in combination. These reactions were rapidly relieved by intramuscular administration of benztropine or diphenhydramine.