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Phospholipid and triglyceride metabolism of excised rat diaphragm and the role of these lipids in fatty acid uptake and oxidation

1960; Elsevier BV; Volume: 1; Issue: 3 Linguagem: Inglês

10.1016/s0022-2275(20)39067-2

1539-7262

E. M. Neptune, H.C. Sudduth, Darhl Foreman, F. J. Fash,

Peroxisome Proliferator-Activated Receptors

After a 48-hour fast, the phospholipid fatty acids of rat diaphragm are reduced much more than the triglyceride fatty acids.Phospholipid thus appears to contribute more to the labile fatty acids than triglyceride.Both long-and short-chain @'-labeled fatty acids are incorporated into triglyceride but only the long-chain fatty acids are incorporated into phospholipid.After incubation with palmitate-14" and transfer to substrate-free Ringer phosphate, triglyceride specific activity decreases but phospholipid specific activity increases.During incubation with palmitate-l-C" the triglyceride specific activity rises, then remains constant.Phospholipid specific activity is initially the same aa triglyceride but rises a t a nearly linear rate.There is net synthesis of triglyceride but not of phospholipid.Combustion of long-chain fatty acids to COg indicates the existence of an endogenous dilution pool.I t is proposed that phospholipids and triglycerides participate in the oxidation of saturated fatty acids.