[Arachidonic acid and prostaglandins, inflammation and oncology].
2001; National Institutes of Health; Volume: 30; Issue: 10 Linguagem: Inglês
Autores
Pascal Eschwège, Victor de Lédinghen, Tura C. Camilli, Sheetal Kulkarni, Guido Dalbagni, S. Droupy, A Jardin, G Benoît, B B Weksler,
Tópico(s)Estrogen and related hormone effects
ResumoCYCLOOXYGENASE PATHWAY: Among the 3 metabolic pathways leading to oxidation of arachidonic acid, the cyclooxygenase (COX) pathway produces prostaglandin G2 that is rapidly transformed into prostaglandin H2. PROSTAGLANDINS: Prostaglandins are inflammation mediators that are strongly implicated in tumorgenesis. They participate in tumor initiation, promotion and growth. INFLAMMATION AND EPITHELIAL CANCER: Chronic inflammation is a risk factor for epithelial cancer. It induces prostaglandin synthesis via activation of COX-2. There is a cause and effect relationship between chronic inflammation and carcinogeneis via COX-2 expression. It has been demonstrated that COX-2 favors tumor invasion and inhibits apoptosis. Tumor growth is favored by PGE2-induced reduction in immunity; COX-2 inhibitors reinforce the immune response. Finally COX-2 is expressed in tumor neovessels and plays a role in angiogenesis.
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