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Fulminant liver failure in a neonate

2016; Wiley; Volume: 52; Issue: 3 Linguagem: Inglês

10.1111/jpc.13090

1440-1754

Naomi E. Clarke, Damien Gilby, Helen Savoia, Mark R Oliver, Sheryle Rogerson,

Metabolism and Genetic Disorders

Neonatal acute liver disease is relatively rare, with multiple different aetiologies including congenital infections, metabolic disorders, gestational alloimmune liver disease, haemophagocytic lymphohistiocytosis, and ischaemic injury. We report a case of neonatal liver failure in a preterm, growth‐restricted infant, who underwent extensive investigation and was clinically diagnosed with gestational alloimmune liver disease, which was confirmed on post‐mortem examination. We then discuss management of neonatal liver failure and gestational alloimmune liver disease, including maternal management in future pregnancies.