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Biparietal diameter/femur length ratio, cephalic index, and femur length measurements: not reliable screening techniques for Down syndrome.

1990; Lippincott Williams & Wilkins; Volume: 75; Issue: 2 Linguagem: Inglês

1873-233X

Shah Yg, Eckl Cj, Stinson Sk, Woods,

Hip and Femur Fractures

Previous published reports have shown that fetuses affected with Down syndrome have normal biparietal diameter (BPD), high BPD-to-femur length ratio, and shorter femur length and occipitofrontal diameter. A retrospective comparison of the BPD, occipitofrontal diameter, cephalic index, femur length, and BPD/femur length ratio was made between 17 fetuses with Down syndrome diagnosed prenatally by second-trimester amniocentesis and 17 matched controls. The gestational age at sonographic evaluation in the two groups ranged from 15-23 weeks. The results of this study show no significant differences in the BPD, occipitofrontal diameter, cephalic index, femur length, and BPD/femur length ratio in the Down syndrome group when compared with controls. The sensitivity of BPD/femur length ratio as a screening technique for Down syndrome in this study was 18%, with a specificity of 94%. This sonographic method does not appear to be a useful screening parameter for Down syndrome.