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Chronic toxicity test of garlic extract in rats

1984; Japanese Society of Toxicological Sciences; Volume: 9; Issue: 1 Linguagem: Inglês

10.2131/jts.9.61

1880-3989

Hiromichi Sumiyoshi, Atsushi Kanezawa, Koji Masamoto, Hiroshi Harada, Satoru Nakagami, Atsuko Yokota, Midori Nishikawa, Shizutoshi Nakagawa,

Garlic and Onion Studies

The influence of garlic extract on the chronic toxicity test were examined orally in Wistar rats for 6 months. There were no toxic symptoms due to garlic extract even at dose level of 2000 mg/kg for 5 times a week during 6 months. High dose of garlic extract did not inhibit the body weight gain, while the food consumption decreased slightly for the nutritional effects of it in both male and female rats. There were no significant differences in urinary, hematological and serological examinations compared each groups. In the histopathological findings, no toxic signs were observed on any of the tissues and organs examined.