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BIBTEX RIS

Identification and Modulatory Activity Assessment of 2-Hydroxy-3,4,6-trimethoxyacetophenone Isolated from Croton anisodontus Mull. Arg.(Euphorbiaceae)

2014; SAGE Publishing; Volume: 9; Issue: 5 Linguagem: Inglês

10.1177/1934578x1400900520

ISSN

1934-578X

Autores

M.T.A. Oliveira, Alexandre Magno Rodrigues Teixeira, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, D.M. Sena, Hélcio Silva dos Santos, Bruna M de Mesquita, Maria Rose Jane R. Albuquerque, Paulo Nogueira Bandeira, Raimundo Braz‐Filho,

Tópico(s)

Phytochemistry and Biological Activities

Resumo

The n-hexane extract of the stem bark of Croton anisodontus yielded 2-hydroxy-3,4,6-trimethoxyacetophenone, a well-known substance, but isolated from this species for the first time. The antimicrobial and modulatory activities of the compound towards Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C. krusei and C. tropicalis strains were assessed. Antibiotics such as amikacin, gentamicin and neomycin were used in a sub-inhibitory concentration. Significant activity was observed towards P. aeruginosa and S. aureus 358, with p < 0.001 in association with amikacin. The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential.

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