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Antineoplastic Agents 470. Absolute Configuration of the Marine Sponge Bromopyrrole Agelastatin A 1

2005; Cognizant Communication Corporation; Volume: 15; Issue: 1 Linguagem: Inglês

10.3727/096504005775082075

1555-3906

George R. Pettit, Sylvie Ducki, Delbert L. Herald, Dennis L. Doubek, Jean M. Schmidt, Jean‐Charles Chapuis,

Synthesis and Reactions of Organic Compounds

Two bromopyrrole marine alkaloids were isolated from the Mexican sponge, Agelas sp.: hymenidin (1) and agelastatin A (2). The structures were elucidated by analysis of their spectroscopic data and found to correspond to those in the literature. The absolute configuration of agelastatin A (2) was elucidated by single-crystal X-ray diffraction methods. Agelastatin A (2) exhibited strong activity against a panel of human cancer cell lines as well as human umbilical vein endothelial cells.