Artigo Acesso aberto Revisado por pares

Biocompatible silk fibroin scaffold prepared by reactive inkjet printing

2016; Springer Science+Business Media; Volume: 51; Issue: 18 Linguagem: Inglês

10.1007/s10853-016-0121-3

ISSN

1573-4803

Autores

Patrick Rider, Yu Zhang, Christopher Tse, Yi Zhang, Dharana Jayawardane, Jonathan Stringer, J. Callaghan, Ian M. Brook, Cheryl A. Miller, Xiubo Zhao, Patrick J. Smith,

Tópico(s)

Electrospun Nanofibers in Biomedical Applications

Resumo

It has recently been shown that regenerated silk fibroin (RSF) aqueous solution can be printed using an inkjet printer. In this communication, we demonstrate an alternative reactive inkjet printing method that provides control over RSF crystallinity through β-sheet concentration. A biocompatible film has successfully been produced through the alternate printing of RSF aqueous solution and methanol using reactive inkjet printing. Control over the formation of the β-sheet structure was achieved by printing different ratios of RSF to methanol and was confirmed using Fourier Transform Infra Red spectroscopy. The biocompatibility of the printed silk scaffold was demonstrated by the growth of fibroblast cells upon its surface.

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