Capítulo de livro Acesso aberto

Oral Cancer: Prevention, Early Detection, and Treatment

2015; Linguagem: Inglês

10.1596/978-1-4648-0349-9_ch5

Autores

Rengaswamy Sankaranarayanan, Kunnambath Ramadas, Hemantha Amarasinghe, Sujha Subramanian, Newell W. Johnson,

Tópico(s)

Oral health in cancer treatment

Resumo

No AccessNov 2015Oral Cancer: Prevention, Early Detection, and TreatmentAuthors/Editors: Rengaswamy Sankaranarayanan, Kunnambath Ramadas, Hemantha Amarasinghe, Sujha Subramanian, Newell JohnsonRengaswamy Sankaranarayanan, Kunnambath Ramadas, Hemantha Amarasinghe, Sujha Subramanian, Newell Johnsonhttps://doi.org/10.1596/978-1-4648-0349-9_ch5AboutView ChaptersFull TextPDF (0.5 MB) ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked In Abstract: Acknowledges that tobacco use and excessive alcohol use significantly raise the risk of oral cancer, and two-thirds of global incidence occurs in South Asia, with India accounting for one-fourth of all oral cancer deaths. In the United States oral cancer incidence and mortality rates have been steadily declining over the past two decades because of declining smoking prevalence and alcohol consumption. Chewing of betel quid and areca nut, especially among youth, explains why oral cancer ranks so high in India. Other risk factors come from mate drinking, viruses, chronic trauma, and genetic factors. Visual screening of the oral cavity, especially when performed by health care personnel, has shown itself to be cost-effective preventive method, even in low-and middle-income countries. Treatment, depending on the cancer stage, consists of surgery and radiotherapy with or without chemotherapy, and may result in side effects from radiotherapy. ReferencesAmagasa, T, M Yamashiro, and N Uzawa. 2011. “Oral Premalignant Lesions: From a Clinical Perspective.” International Journal of Clinical Oncology 16 (1): 5–14. CrossrefGoogle ScholarAmarasinghe, H K, N W Johnson, R Lalloo, M Kumaraarachchi, and S Warnakulasuriya. 2010. “Derivation and Validation of a Risk-Factor Model for Detection of Oral Potentially Malignant Disorders in Populations with High Prevalence.” British Journal of Cancer 103 (3): 303–09. CrossrefGoogle ScholarBernier, J, C Domenge, M Ozsahin, K Matuszewska, and J L Lefebvre, and others. 2004. “Postoperative Irradiation with or Without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer.” New England Journal of Medicine 350 (19): 1945–52. CrossrefGoogle ScholarBhurgri, Y, A Bhurgri, A Usman, S Pervez, and N Kayani and others. 2006. “Epidemiological Review of Head and Neck Cancers in Karachi.” Asian Pacific Journal of Cancer Prevention 7 (2): 195–200. Google ScholarBlanchard, P, B Baujat, V Holostenco, A Bourredjem, and C Baey and others. 2011. “Meta-Analysis of Chemotherapy in Head and Neck Cancer (MACH-NC): A Comprehensive Analysis by Tumour Site.” Radiotherapy and Oncology 100 (1): 33–40. CrossrefGoogle ScholarBonifazi, M, M Malvezzi, P Bertuccio, V Edefonti, and W Garavello and others. 2011. “Age-Period-Cohort Analysis of Oral Cancer Mortality in Europe: The End of an Epidemic?” Oral Oncology 47 (5): 400–07. CrossrefGoogle ScholarBray, F, J S Ren, E Masuyer, and J Ferlay. 2013. “Estimates of Global Cancer Prevalence for 27 Sites in the Adult Population in 2008.” International Journal of Cancer 132 (5): 1133–45. CrossrefGoogle ScholarBrocklehurst, P, O Kujan, L A O’Malley, G Ogden, S Shepherd, and A M Glenny. 2013. “Screening Programmes for the Early Detection and Prevention of Oral Cancer.” Cochrane Database of Systematic Reviews 11: CD004150. Google ScholarBrown, L M, D P Check, and S S Devesa. 2011. “Oropharyngeal Cancer Incidence Trends: Diminishing Racial Disparities.” Cancer Causes and Control 22 (5): 753–63. CrossrefGoogle ScholarChainani-Wu, N, J Epstein, and R Touger-Decker. 2011. “Diet and Prevention of Oral Cancer: Strategies for Clinical Practice.” Journal of the American Dental Association 142 (2): 166–69. CrossrefGoogle ScholarCooper, J S, T F Pajak, A A Forastiere, J Jacobs, and B H Campbell, and others. 2004. “Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck.” New England Journal of Medicine 350 (19): 1937–44. CrossrefGoogle ScholarDedhia, R C, K J Smith, J T Johnson, and M Roberts. 2011. “The Cost-Effectiveness of Community-Based Screening for Oral Cancer in High-Risk Males in the United States: A Markov Decision Analysis Approach.” Laryngoscope 121 (5): 952–60. CrossrefGoogle ScholarDeneo-Pellegrini, H, E De Stefani, P Boffetta, A L Ronco, and G Acosta and others. 2012. “Mate Consumption and Risk of Oral Cancer: Case-Control Study in Uruguay.” Head & Neck 35 (8): 1091–95. CrossrefGoogle ScholarDowner, M C, D R Moles, S Palmer, and P M Speight. 2004. “A Systematic Review of Test Performance in Screening for Oral Cancer and Precancer.” Oral Oncology 40 (3): 264–73. CrossrefGoogle ScholarEdwards, C P 2013. “Oral Cancer Screening for Asymptomatic Adults: Do the United States Preventive Services Task Force Draft Guidelines Miss the Proverbial Forest for the Trees?” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 116 (2): 131–34. Google ScholarElango, K J, N Anandkrishnan, A Suresh, S K Iyer, and S K Ramaiyer, and others. 2011. “Mouth Self-Examination to Improve Oral Cancer Awareness and Early Detection in a High-Risk Population.” Oral Oncology 47 (7): 620–24. CrossrefGoogle ScholarEl-Naaj, I A, Y Leiser, M Shveis, E Sabo, and M Peled. 2011. “Incidence of Oral Cancer Occult Metastasis and Survival of T1-T2N0 Oral Cancer Patients.” Journal of Oral & Maxillofacial Surgery 69 (10): 2674–79. CrossrefGoogle ScholarFerlay, J, I Soerjomataram, M Ervik, R Dikshit, and S Eser and others. 2013. GLOBOCAN 2012 V1.0, Cancer Incidence and Mortality Worldwide: IARC Cancerbase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer. http://globocan.iarc.fr. Google ScholarFernandez, G L, R Sankaranarayanan, J J Lence Anta, S A Rodriguez, and D M Parkin. 1995. “An Evaluation of the Oral Cancer Control Program in Cuba.” Epidemiology 6 (4): 428–31. CrossrefGoogle ScholarForman, D, F Bray, D H Brewster, C Mbalawa Gombe, and B Kohler and others. 2013. Cancer Incidence in Five Continents. Vol. 10 (Electronic Version). Lyon, France: International Agency for Cancer. http://ci5.iarc.fr. Google ScholarFujita, M, Y Hirokawa, K Kashiwado, Y Akagi, and K Kashimoto and others. 1999. “Interstitial Brachytherapy for Stage I and II Squamous Cell Carcinoma of the Oral Tongue: Factors Influencing Local Control and Soft Tissue Complications.” International Journal of Radiation Oncology Biology Physics 44 (4): 767–75. CrossrefGoogle ScholarGandini, S, E Negri, P Boffetta, V C La, and P Boyle. 2012. “Mouthwash and Oral Cancer Risk Quantitative Meta-Analysis of Epidemiologic Studies.” Annals of Agricultural and Environmental Medicine 19 (2): 173–80. Google ScholarGupta, B, A Ariyawardana, and N W Johnson. 2013. “Oral Cancer in India Continues in Epidemic Proportions: Evidence Base and Policy Initiatives.” International Dental Journal 63 (1): 12–25. CrossrefGoogle ScholarGupta, P C, C S Ray, D N Sinha, and P K Singh. 2011. “Smokeless Tobacco: A Major Public Health Problem in the SEA Region: A Review.” Indian Journal of Public Health 55 (3): 199–209. CrossrefGoogle ScholarHarty, L C, N E Caporaso, R B Hayes, D M Winn, and E Bravo-Otero and others. 1997. “Alcohol Dehydrogenase 3 Genotype and Risk of Oral Cavity and Pharyngeal Cancers.” Journal of the National Cancer Institute 89 (22): 1698–705. CrossrefGoogle ScholarHeck, J E, J Berthiller, S Vaccarella, D M Winn, and E M Smith, and others. 2010. “Sexual Behaviours and the Risk of Head and Neck Cancers: A Pooled Analysis in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.” International Journal of Epidemiology 39 (1): 166–81. CrossrefGoogle ScholarHicks, W L, Jr, T R Loree, R I Garcia, S Maamoun, and D Marshall and others. 1997. “Squamous Cell Carcinoma of the Floor of Mouth: A 20-Year Review.” Head & Neck 19 (5): 400–05. CrossrefGoogle ScholarHirsch, J M, M Wallstrom, A P Carlsson, and L Sand. 2012. “Oral Cancer in Swedish Snuff Dippers.” Anticancer Research 32 (8): 3327–30. Google ScholarHowlader, N, L A Ries, A B Mariotto, M E Reichman, and J Ruhl and others. 2010. “Improved Estimates of Cancer-Specific Survival Rates from Population-Based Data.” Journal of the National Cancer Institute 102 (20): 1584–98. CrossrefGoogle ScholarHsue, S S, W C Wang, C H Chen, C C Lin, Y K Chen, and L M Lin. 2007. “Malignant Transformation in 1458 Patients with Potentially Malignant Oral Mucosal Disorders: A Follow-Up Study Based in a Taiwanese Hospital.” Journal of Oral Pathology & Medicine 36 (1): 25–29. CrossrefGoogle ScholarIARC (International Agency for Research on Cancer). 2004a. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 83: Tobacco Smoke and Involuntary Smoking. Lyon, France: IARC. Google ScholarIARC (International Agency for Research on Cancer). 2004b. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 85: Betel-Quid and Areca-Nut Derived Nitrosamines. Lyon, France: IARC. Google ScholarIARC (International Agency for Research on Cancer) 2007. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 89: Smokeless Tobacco and Some Tobacco-Specific N-Nitrosamines. Lyon, France: IARC. Google ScholarIARC (International Agency for Research on Cancer) 2010. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 96: Alcohol Consumption and Ethyl Carbamate. Lyon, France: IARC. Google ScholarJaved, F, M Chotai, A Mehmood, and K Almas. 2010. “Oral Mucosal Disorders Associated with Habitual Gutka Usage: A Review.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 109 (6): 857–64. CrossrefGoogle ScholarJohnson, N W, S Warnakulasuriya, P C Gupta, E Dimba, and M Chindia and others. 2011. “Global Oral Health Inequalities in Incidence and Outcomes for Oral Cancer: Causes and Solutions.” Advances in Dental Research 23 (2): 237–46. CrossrefGoogle ScholarLambert, R, C Sauvaget, C M De Camargo, and R Sankaranarayanan. 2011. “Epidemiology of Cancer from the Oral Cavity and Oropharynx.” European Journal of Gastroenterology & Hepatology 23 (8): 633–41. CrossrefGoogle ScholarLicitra, L, C Grandi, M Guzzo, L Mariani, and V S Lo, and others. 2003. “Primary Chemotherapy in Resectable Oral Cavity Squamous Cell Cancer: A Randomized Controlled Trial.” Journal of Clinical Oncology 21 (2): 327–33. CrossrefGoogle ScholarLu, D, X Yu, and Y Du. 2011. “Meta-Analyses of the Effect of Cytochrome P450 2E1 Gene Polymorphism on the Risk of Head and Neck Cancer.” Molecular Biology Reports 38 (4): 2409–16. CrossrefGoogle ScholarLucenteforte, E, W Garavello, C Bosetti, and V C La. 2009. ”Dietary Factors and Oral and Pharyngeal Cancer Risk.” Oral Oncology 45 (6): 461–67. CrossrefGoogle ScholarLundahl, R E, R L Foote, J A Bonner, V J Suman, and J E Lewis, and others. 1998. “Combined Neck Dissection and Postoperative Radiation Therapy in the Management of the High-Risk Neck: A Matched-Pair Analysis.” International Journal of Radiation Oncology Biology Physics 40 (3): 529–34. CrossrefGoogle ScholarMarsiglia, H, C Haie-Meder, G Sasso, G Mamelle, and A Gerbaulet. 2002. “Brachytherapy for T1-T2 Floor-of-the-Mouth Cancers: The Gustave-Roussy Institute Experience.” International Journal of Radiation Oncology Biology Physics 52 (5): 1257–63. CrossrefGoogle ScholarMathew, B, R Sankaranarayanan, K B Sunilkumar, B Kuruvila, and P Pisani and others. 1997. “Reproducibility and Validity of Oral Visual Inspection by Trained Health Workers in the Detection of Oral Precancer and Cancer.” British Journal of Cancer 76 (3): 390–94. CrossrefGoogle ScholarMathew, B, R Sankaranarayanan, R Wesley, and M K Nair. 1995. “Evaluation of Mouth Self-Examination in the Control of Oral Cancer.” British Journal of Cancer 71 (2): 397–99. CrossrefGoogle ScholarMehta, F S, P C Gupta, R B Bhonsle, P R Murti, D K Daftary, and J J Pindborg. 1986. “Detection of Oral Cancer Using Basic Health Workers in an Area of High Oral Cancer Incidence in India.” Cancer Detection and Prevention 9 (3–4):219–25. Google ScholarNapier, S S and P M Speight. 2008. “Natural History of Potentially Malignant Oral Lesions and Conditions: An Overview of the Literature.” Journal of Oral Pathology & Medicine 37 (1): 1–10. CrossrefGoogle ScholarPatel, S G and J P Shah. 2005. “TNM Staging of Cancers of the Head and Neck: Striving for Uniformity among Diversity.” CA: A Cancer Journal for Clinicians 55 (4): 242–58. CrossrefGoogle ScholarPatton, L L, J B Epstein, and A R Kerr. 2008. “Adjunctive Techniques for Oral Cancer Examination and Lesion Diagnosis: A Systematic Review of the Literature.” Journal of the American Dental Association 139 (7): 896–905. CrossrefGoogle ScholarPavia, M, C Pileggi, C G Nobile, and I F Angelillo. 2006. “Association between Fruit and Vegetable Consumption and Oral Cancer: A Meta-Analysis of Observational Studies.” American Journal of Clinical Nutrition 83 (5): 1126–34. Google ScholarPiemonte, E D, J P Lazos, and M Brunotto. 2010. “Relationship between Chronic Trauma of the Oral Mucosa, Oral Potentially Malignant Disorders and Oral Cancer.” Journal of Oral Pathology & Medicine 39 (7): 513–17. Google ScholarPrabhu, S and D Wilson. 2013. “Human Papillomavirus and Oral Disease: Emerging Evidence: A Review.” Australian Dental Journal 58 (1): 2–10. CrossrefGoogle ScholarPulte, D and H Brenner. 2010. “Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis.” Oncologist 15 (9): 994–1001. CrossrefGoogle ScholarRadoi, L, S Paget-Bailly, D Cyr, A Papadopoulos, and F Guida and others. 2013. “Tobacco Smoking, Alcohol Drinking and Risk of Oral Cavity Cancer by Subsite: Results of a French Population-Based Case-Control Study, the ICARE Study.” European Journal of Cancer Prevention 22 (3): 268–76. CrossrefGoogle ScholarRamadas, K, E Lucas, G Thomas, B Mathew, and A Balan and others. 2008. A Digital Manual for the Early Diagnosis of Oral Neoplasia. Lyon, France: International Agency for Research on Cancer. http://screening.iarc.fr/atlasoral.php. Google ScholarRethman, M P, W Carpenter, E E Cohen, J Epstein, and C A Evans., and others. 2010. “Evidence-Based Clinical Recommendations Regarding Screening for Oral Squamous Cell Carcinomas.” Journal of the American Dental Association 141 (5): 509–20. CrossrefGoogle ScholarRichards, D 2010. “Does Toluidine Blue Detect More Oral Cancer?” Evidence-Based Dental Practice 11 (4): 104–05. CrossrefGoogle ScholarRies, L A G, D Melbert, M Krapcho, D G Stinchcomb, and N Howlader and others. 2008. Cancer Statistics Review, 1975–2005. Bethesda, MD: National Cancer Institute. http://seer.cancer.gov/csr/1975-2005. Google ScholarSaba, N F, M Goodman, K Ward, C Flowers, and S Ramalingam and others. 2011. “Gender and Ethnic Disparities in Incidence and Survival of Squamous Cell Carcinoma of the Oral Tongue, Base of Tongue, and Tonsils: A Surveillance, Epidemiology and End Results Program-Based Analysis.” Oncology 81 (1): 12–20. CrossrefGoogle ScholarSankaranarayanan, R, K Ramadas, S Thara, R Muwonge, and G Thomas and others. 2013. “Long Term Effect of Visual Screening on Oral Cancer Incidence and Mortality in a Randomized Trial in Kerala, India.” Oral Oncology 49 (4): 314–21. CrossrefGoogle ScholarSankaranarayanan, R, K Ramadas, G Thomas, R Muwonge, and S Thara and others. 2005. “Effect of Screening on Oral Cancer Mortality in Kerala, India: A Cluster-Randomised Controlled Trial.” The Lancet 365 (9475): 1927–33. CrossrefGoogle ScholarSankaranarayanan, R and R Swaminathan. 2011. Cancer Survival in Africa, Asia, the Caribbean and Central America. Scientific Publications No. 162. Lyon, France: International Agency for Research on Cancer. Google ScholarSankaranarayanan, R, R Swaminathan, H Brenner, K Chen, and K S Chia, and others. 2010. “Cancer Survival in Africa, Asia, and Central America: A Population-Based Study.” The Lancet Oncology 11 (2): 165–73. CrossrefGoogle ScholarSant, M, C Allemani, M Santaquilani, A Knijn, and F Marchesi and others. 2009. “EUROCARE-4. Survival of Cancer Patients Diagnosed in 1995–1999.Results and Commentary.” European Journal of Cancer 45 (6): 931–91. CrossrefGoogle ScholarSatyanarayana, L and S Asthana. 2008. “Life Time Risk for Development of Ten Major Cancers in India and Its Trends over the Years 1982 to 2000.” Indian Journal of Medical Sciences 62 (2): 35–44. CrossrefGoogle ScholarScott, S E, K Rizvi, E A Grunfeld, and M Mcgurk. 2010. “Pilot Study to Estimate the Accuracy of Mouth Self-Examination in an At-Risk Group.” Head & Neck 32 (10): 1393–401. CrossrefGoogle ScholarSinha, D N, K M Palipudi, I Rolle, S Asma, and S Rinchen. 2011. “Tobacco Use among Youth and Adults in Member Countries of South-East Asia Region: Review of Findings from Surveys under the Global Tobacco Surveillance System.” Indian Journal of Public Health 55 (3): 169–76. CrossrefGoogle ScholarSobin, L H and C Wittekind. 2002. UICC TNM Classification of Malignant Tumours. Geneva: Union for International Cancer Control. Google ScholarSomatunga, L C, D N Sinha, P Sumanasekera, K Galapatti, and S Rinchen and others. 2012. “Smokeless Tobacco Use in Sri Lanka.” Indian Journal of Cancer 49 (4): 357–63. CrossrefGoogle ScholarSpeight, P M, S Palmer, D R Moles, M C Downer, and D H Smith and others. 2006. “The Cost-Effectiveness of Screening for Oral Cancer in Primary Care.” Health Technology Assessment 10 (14): 1–144, Iii-Iv. CrossrefGoogle ScholarSu, W W, A M Yen, S Y Chiu, and T H Chen. 2010. “A Community-Based RCT for Oral Cancer Screening with Toluidine Blue.” Journal of Dental Research 89 (9): 933–37. CrossrefGoogle ScholarSubramanian, S, R Sankaranarayanan, B Bapat, T Somanathan, and G Thomas and others. 2009. “Cost-Effectiveness of Oral Cancer Screening: Results from a Cluster Randomized Controlled Trial in India.” Bulletin of the World Health Organization 87 (3): 200–06. CrossrefGoogle ScholarTseng, C H 2013. “Oral Cancer in Taiwan: Is Diabetes a Risk Factor?” Clinical Oral Investigations 17 (5): 1357–64. CrossrefGoogle ScholarMeij Van Der, E H, P D Bezemer, and I Van Der Waal. 2002. “Cost-Effectiveness of Screening for the Possible Development of Cancer in Patients with Oral Lichen Planus.” Community Dentistry and Oral Epidemiology 30 (5): 342–51. CrossrefGoogle ScholarVijayakumar, M, R Burrah, K S Sabitha, H Nadimul, and B C Rajani. 2011. “To Operate or Not to Operate: N0 Neck in Early Cancer of the Tongue? A Prospective Study.” Indian Journal of Surgical Oncology 2 (3): 172–75. CrossrefGoogle ScholarWalsh, T, J L Liu, P Brocklehurst, A M Glenny, and M Lingen and others. 2013. “Clinical Assessment to Screen for Oral Cavity Cancer and Potentially Malignant Disorders in Apparently Healthy Adults.” Cochrane Database of Systematic Reviews 11: CD010173. Google ScholarWarnakulasuriya, K A, A N Ekanayake, S Sivayoham, J Stjernsward, and J J Pindborg., and others. 1984. “Utilization of Primary Health Care Workers for Early Detection of Oral Cancer and Precancer Cases in Sri Lanka.” Bulletin of the World Health Organization 62 (2): 243–50. Google ScholarWarnakulasuriya, S, N W Johnson, and I Van Der Waal. 2007. “Nomenclature and Classification of Potentially Malignant Disorders of the Oral Mucosa.” Journal of Oral Pathology & Medicine 36 (10): 575–80. CrossrefGoogle ScholarWarnakulasuriya, K A and B G Nanayakkara 1991. “Reproducibility of an Oral Cancer and Precancer Detection Program Using a Primary Health Care Model in Sri Lanka.” Cancer Detection and Prevention 15 (5): 331–34. Google ScholarWendt, C D, L J Peters, L Delclos, K K Ang, and W H Morrison, and others. 1990. “Primary Radiotherapy in the Treatment of Stage I and II Oral Tongue Cancers: Importance of the Proportion of Therapy Delivered with Interstitial Therapy.” International Journal of Radiation Oncology Biology Physics 18 (6): 1287–92. CrossrefGoogle ScholarWoolgar, J A 2006. “Histopathological Prognosticators in Oral and Oropharyngeal Squamous Cell Carcinoma.” Oral Oncology 42 (3): 229–39. CrossrefGoogle ScholarWorld Cancer Research Fund and AICR (American Institute for Cancer Research). 2007. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, DC: AICR. Google ScholarWrangle, J M and F R Khuri. 2007. “Chemoprevention of Squamous Cell Carcinoma of the Head and Neck.” Current Opinion in Oncology 19 (3): 180–87. CrossrefGoogle ScholarYako-Suketomo, H and T Matsuda. 2010. “Comparison of Time Trends in Lip, Oral Cavity and Pharynx Cancer Mortality (1990–2006) between Countries Based on the WHO Mortality Database.” Japanese Journal of Clinical Oncology 40 (11): 1118–19. CrossrefGoogle ScholarZwetyenga, N, C Majoufre-Lefebvre, F Siberchicot, H Demeaux, and J Pinsolle. 2003. “[Squamous-cell carcinoma of the tongue: treatment results and prognosis].” Revue de stomatologie et de chirurgie maxillo-faciale 104 (1): 10–17. 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