Myasthenia Gravis in a Patient with Chronic Myeloid Leukemia Treated by Busulfan
1968; Elsevier BV; Volume: 32; Issue: 2 Linguagem: Inglês
10.1182/blood.v32.2.336.336
ISSN1528-0020
AutoresM Djaldetti, J Pinkhas, André de Vries, Edna Kott, H Joshua, L Dollberg,
Tópico(s)Cancer Treatment and Pharmacology
ResumoAbstract Myasthenia gravis and roentgenologic evidence of a mass in the anterior mediastinum appeared in a patient with chronic myeloid leukemia following busulfan treatment. X-ray irradiation of the thymic area and subsequent surgical removal of the anterior mediastinal mass were followed by remission from the myasthenia gravis. Histologic examination of the mass showed involuted thymic remnants without evidence of leukemic infiltration or of malignant thymoma. The possible etiology of the myasthenia gravis in this patient, with special reference to a busulfan-induced autoimmune process, is discussed.
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