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From Membrane to Cytoskeleton

1999; Cell Press; Volume: 22; Issue: 3 Linguagem: Inglês

10.1016/s0896-6273(00)80696-0

1097-4199

Song Hu, Louis F. Reichardt,

Microtubule and mitosis dynamics

During development, neurons migrate and undergo extensive morphological changes necessary to establish functional connections. Extracellular cues function through surface receptors to control signaling pathways whose interplay results in the remodeling of the cytoskeleton and thereby changes in cell shape and motility. Past research has identified numerous receptors as important for promoting or directing cell and growth cone movements. Compared with the explosion in information on these surface interactions, however, little is known about the intracellular signaling mechanisms that direct cell motility. Recent work, published in this journal and described in this minireview, has identified a receptor (tyrosine phosphatase, Dlar) and a signaling pathway (Abl kinase) important in regulating axon guidance. These studies provide a provocative link from the cell surface to the actin cytoskeleton through the Ena/VASP family of proteins and Profilin, both of which are known to regulate actin dynamics and are shown in these papers to play important roles in axon growth and guidance.