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Diastolic intramyocardial tissue pressure before, during, and after temporary occlusion of the left anterior descending coronary artery

1974; Elsevier BV; Volume: 67; Issue: 3 Linguagem: Inglês

10.1016/s0022-5223(19)40505-9

1097-685X

Robert G. Peyster, Jackson H. Stuckey,

Cardiovascular Function and Risk Factors

Diastolic intramyocardial tissue pressure (DIMP) was measured in 7 dogs before, during, and after occlusion of the left anterior descending coronary artery for 60 minutes and in 5 control dogs in which the artery was not occluded. A significant increase in DIMP (p < 0.005) was demonstrated in the period following release of the occlusion; a small decrease in DIMP was present in the 5 control dogs after the same period of time. The rise in DIMP following temporary coronary artery occlusion provides a plausible explanation for the pathogenesis of the microcirculatory perfusion deficit in the previously ischemic area. This finding has relevance to myocardial "revival time" and casts doubt on the practice of alternating brief periods of coronary artery perfusion with extended periods of ischemia during cardiac surgery done with the aid of total cardiopulmonary bypass.