Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats

2016; Elsevier BV; Volume: 151; Linguagem: Inglês

10.1016/j.carbpol.2016.06.047

1879-1344

Tarcísio Vieira de Brito, Francisco Clark Nogueira Barros, Renan O. Silva, Genilson José Dias Júnior, José Simião C. Júnior, Álvaro Xavier Franco, Pedro Marcos Gomes Soares, Luciano S. Chaves, Clara M.W.S. Abreu, Regina C.M. de Paula, Marcellus Henrique Loiola Ponte de Souza, Ana Lúcia Ponte Freitas, André Luiz dos Reis Barbosa,

Polysaccharides and Plant Cell Walls

Sulfated polysaccharides extracted from seaweed have important pharmacological properties. Thus, the aim of this study was to characterize the sulfated polysaccharide (PLS) from the algae Hypnea musciformis and evaluate its protective effect in colitis induced by trinitrobenzene sulfonic acid in rats. The sulfated polysaccharide possess a high molecular mass (1.24×10(5)gmol(-1)) and is composed of a κ-carrageenan, as depicted by FT-IR and NMR spectroscopic data. PLS was administered orally (10, 30, and 60mg/kg, p.o.) for three days, starting before TNBS (trinitrobenzene sulfonic acid) instillation (day 1). The rats were killed on day three, the portion of distal colon (5cm) was excised and evaluated macroscopic scores and wet weight. Then, samples of the intestinal were used for histological evaluation and quantification of glutathione, malonyldialdehyde acid, myeloperoxidase, nitrate/nitrite and cytokines. Our results demonstrate that PLS reduced the colitis and all analyzed biochemical parameters. Thus, we concluded that the PLS extracted from the marine algae H. musciformis reduced the colitis in animal model and may have an important promising application in the inflammatory bowel diseases.