Produção Nacional
Revisado por pares
Update on melatonin receptors: IUPHAR Review 20
2016; Wiley; Volume: 173; Issue: 18 Linguagem: Inglês
10.1111/bph.13536
ISSN1476-5381
AutoresRalf Jockers, Philippe Delagrange, Margarita L. Dubocovich, Regina P. Markus, Nicolas Renault, Gianluca Tosini, Erika Cecon, Darius P. Zlotos,
Tópico(s)Cholesterol and Lipid Metabolism
ResumoMelatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist ‐ MT 1 and MT 2 ‐ encoded by the MTNR1A and MTNR1B genes respectively. The current review provides an update on melatonin receptors by the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology. We will highlight recent developments of melatonin receptor ligands, including radioligands, and give an update on the latest phenotyping results of melatonin receptor knockout mice. The current status and perspectives of the structure of melatonin receptor will be summarized. The physiological importance of melatonin receptor dimers and biologically important and type 2 diabetes‐associated genetic variants of melatonin receptors will be discussed. The role of melatonin receptors in physiology and disease will be further exemplified by their functions in the immune system and the CNS. Finally, antioxidant and free radical scavenger properties of melatonin and its relation to melatonin receptors will be critically addressed.
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