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Real-world treatment patterns and associated progression-free survival in relapsed/refractory multiple myeloma among US community oncology practices

2016; Taylor & Francis; Volume: 9; Issue: 7 Linguagem: Inglês

10.1080/17474086.2016.1195254

1747-4086

Sundar Jagannath, Anuja Roy, Jonathan Kish, Orsolya Lunacsek, Denise Globe, Michael Eaddy, Emil Kuriakose, Joanne Willey, Stephanie Butler-Bird, David S. Siegel,

Myeloproliferative Neoplasms: Diagnosis and Treatment

Evidence supporting optimal treatment sequencing in relapsed/refractory multiple myeloma (RRMM) patients requiring multiple therapy lines is lacking.Using retrospective chart data, this study describes real-world RRMM treatment patterns and related progression-free survival (PFS) in US community oncology clinics.Bortezomib ± a non-immunomodulatory drug (IMiD), lenalidomide ± a non-proteasome inhibitor (PI), bortezomib + an IMiD were the most commonly used regimens in early lines of therapy. Median PFS was similar in 1(st) (11.1 months) and 2(nd) line (10.5) and decreased in lines 3 through 5 (3(rd): 7.9; 4(th): 7.2, 5(th): 5.4). Longest PFS (12.5 months) in first line was with bortezomib + ImiD; longest PFS in second line was with lenalidomide ± a non-PI was (13.2 months).Re-treatment with bortezomib was common; novel agents were reserved for later therapy lines. Overall, the observed PFS associated with real-world treatment sequences were shorter than those reported in clinical trials.