Very Low Dose Amitriptyline for Clozapine-Associated Sialorrhea
2016; Bentham Science Publishers; Volume: 11; Issue: 3 Linguagem: Inglês
10.2174/1574886311666160426130252
ISSN2212-3911
AutoresSiddhartha Sinha, Jayati Simlai, Samir Kumar Praharaj,
Tópico(s)Peripheral Neuropathies and Disorders
ResumoClozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87–100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect. Keywords: Clozapine, amitriptyline, sialorrhea, hypersalivation.
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