Experimental E. coli arthritis in the rabbit. A model of infectious and post-infectious inflammatory synovitis.
1977; The Journal of Rheumatology Publishing Company Limited; Volume: 4; Issue: 2 Linguagem: Inglês
ISSN
1499-2752
AutoresSchurman Dj, JosephM. Mirra, Aihao Ding, Nagel Da,
Tópico(s)Osteoarthritis Treatment and Mechanisms
ResumoRabbit knee joints challenged with E. coli 06 underwent a self-limited infection lasting several weeks followed by a prolonged post-infectious inflammatory arthritis. The E. coli used did not possess collagenolytic activity nor did a variety of common aerobic clinical isolates. Articular cartilage destruction occurred by two basically different mechanisms: u) direct invasion of pannus at the juxtaarticular margins, and 2) fibrillation in cartilage to cartilage contact areas. Weekly measurement of intra-articular pH and temperature were correlated with bacteriologic findings and groww and microscopic pathologic events.
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