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Effect of Pharmaceutical Adjuvant on Absorption of Drugs Effect of Magnesium Aluminosilicate on Absorption of Aspirin in Man

1974; Pharmaceutical Society of Japan; Volume: 94; Issue: 11 Linguagem: Inglês

10.1248/yakushi1947.94.11_1353

1347-5231

SHIKIFUMI KITAZAWA, KATSUMI SAKAI, Hiroshi MURASAKI,

Drug Solubulity and Delivery Systems

The effect of magnesium aluminosilicate (MAS) on the absorption of aspirin was investigated with five young healthy volunteers. The volunteers were administered 1 g of the drug alone (control study) or with 300 mg (case-1 study) and/or 600 mg (case-2 study) of MAS, and the order of these studies was randomly designed. After each administration of the drug, the blood samples at a given time and the urine of up to 34 hr were collected, and the levels of the drug were determined. Because of almost the same results in the blood level and the excretion of the drug were obtained in each case of the control, the case-1 and case-2 studies, it would be possible to conclude from these data of such a balanced study that MAS did not affect the absorption of aspirin in man.