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Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

2016; National Academy of Sciences; Volume: 113; Issue: 28 Linguagem: Inglês

10.1073/pnas.1607931113

1091-6490

Lalita Priyamvada, Kendra M. Quicke, William Henry Hudson, Nattawat Onlamoon, Jaturong Sewatanon, Srilatha Edupuganti, Kovit Pattanapanyasat, Kulkanya Chokephaibulkit, Mark J. Mulligan, Patrick C. Wilson, Rafi Ahmed, Mehul S. Suthar, Jens Wrammert,

Virology and Viral Diseases

Significance In this study, we address the issue of cross-reactivity between dengue virus (DENV) and Zika virus (ZIKV) by testing sera and plasmablast-derived monoclonal antibodies from dengue patients against ZIKV. We show that both acute and convalescent dengue sera potently bind and neutralize ZIKV and that this cross-reactivity is also evident at the monoclonal level. We also demonstrate in vitro antibody-dependent enhancement of ZIKV infection in the presence of dengue-induced antibodies. Our findings strongly suggest that preexisting dengue antibodies may modulate immune responses to ZIKV infection. These data are timely and highly relevant from a public health standpoint given that a majority of regions currently experiencing Zika virus epidemics are endemic for dengue.