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The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

2016; Rockefeller University Press; Volume: 213; Issue: 6 Linguagem: Inglês

10.1083/jcb.201602089

1540-8140

Deepika Sharma, Thirumala‐Devi Kanneganti,

Heme Oxygenase-1 and Carbon Monoxide

Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.