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Bioassay on Polyvinylpyrrolidones With Limited Molecular Weight Range

1961; Oxford University Press; Linguagem: Inglês

10.1093/jnci/26.1.229

1460-2105

W. C. Hueper,

Pharmaceutical studies and practices

Two specially prepared polyvinylpyrrolidones (PVP's), one with a molecular weight range between about 2,000 and 38,000 and the other with a molecular weight range from approximately 4,000 to 80,000, were injected repeatedly as 25 percent solutions in physiologic saline into the abdominal cavities of rats and rabbits. The macromolecular material of both PVP's was retained in the organs of rats despite the relatively low maximal molecular weight of one of the PVP's. However, this PVP passed the glomerular filter of the rabbits and thus was not stored. The glomerular filter of rats and rabbits differed in pore size. The degree of storage of the PVP's tested did not exert any stimulating effect upon the production of cancers. In fact, there was evidence that one of two PVP's used for comparative purposes and having an average molecular weight of 50,000 might have interfered with the development of spontaneous cancers. Whenever carcinogenic properties of PVP's were present, they did not seem to be related to any physical properties of the macromolecules.