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Neuroinflammation pathways: a general review

2016; Taylor & Francis; Volume: 127; Issue: 7 Linguagem: Inglês

10.1080/00207454.2016.1212854

1563-5279

Tara Shabab, Ramin Khanabdali, Soheil Zorofchian Moghadamtousi, Habsah Abdul Kadir, Gokula Mohan,

Nuclear Receptors and Signaling

Activated microglial cells play an important role in immune and inflammatory responses in central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are mediated by signaling molecules that are produced during neuroinflammation. In glial cells, NF-κB, a transcription factor, initiates and regulates the expression of several inflammatory processes during inflammation which are attributed to the pathology of the several neurodegenerative diseases. In this review, we discuss the most important neuroinflammatory mediators with their pathways. Attenuating cytokines production and controlling microglial inflammatory response, which are the result of understanding neuroinflammation pathways, are considered therapeutic strategies for treating neurodegenerative diseases with an inflammatory component.