In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma
2016; American Chemical Society; Volume: 2; Issue: 7 Linguagem: Inglês
10.1021/acscentsci.6b00150
ISSN2374-7951
AutoresJosé M. Mejía Oneto, Irfan Khan, Leah M. Seebald, Maksim Royzen,
Tópico(s)Cancer Research and Treatments
ResumoThe ability to activate drugs only at desired locations avoiding systemic immunosuppression and other dose limiting toxicities is highly desirable. Here we present a new approach, named local drug activation, that uses bioorthogonal chemistry to concentrate and activate systemic small molecules at a location of choice. This method is independent of endogenous cellular or environmental markers and only depends on the presence of a preimplanted biomaterial near a desired site (e.g., tumor). We demonstrate the clear therapeutic benefit with minimal side effects of this approach in mice over systemic therapy using a doxorubicin pro-drug against xenograft tumors of a type of soft tissue sarcoma (HT1080).
Referência(s)